Matches in SemOpenAlex for { <https://semopenalex.org/work/W2133392557> ?p ?o ?g. }
- W2133392557 endingPage "70" @default.
- W2133392557 startingPage "60" @default.
- W2133392557 abstract "ABSTRACT The entry of human cytomegalovirus (HCMV) into biologically relevant epithelial and endothelial cells involves endocytosis followed by low-pH-dependent fusion. This entry pathway is facilitated by the HCMV UL128, UL130, and UL131 proteins, which form one or more complexes with the virion envelope glycoprotein gH/gL. gH/gL/UL128-131 complexes appear to be distinct from the gH/gL/gO complex, which likely facilitates entry into fibroblasts. In order to better understand the assembly and protein-protein interactions of gH/gL/UL128-131 complexes, we generated HCMV mutants lacking UL128-131 proteins and nonreplicating adenovirus vectors expressing gH, gL, UL128, UL130, and UL131. Our results demonstrate that UL128, UL130, and UL131 can each independently assemble onto gH/gL scaffolds. However, the binding of individual UL128-131 proteins onto gH/gL can significantly affect the binding of other proteins; for example, UL128 increased the binding of both UL130 and UL131 to gH/gL. Direct interactions between gH/UL130, UL130/UL131, gL/UL128, and UL128/UL130 were also observed. The export of gH/gL complexes from the endoplasmic reticulum (ER) to the Golgi apparatus and cell surface was dramatically increased when all of UL128, UL130, and UL131 were coexpressed with gH/gL (with or without gO expression). Incorporation of gH/gL complexes into the virion envelope requires transport beyond the ER. Thus, we concluded that UL128, UL130, and UL131 must all bind simultaneously onto gH/gL for the production of complexes that can function in entry into epithelial and endothelial cells." @default.
- W2133392557 created "2016-06-24" @default.
- W2133392557 creator A5014390186 @default.
- W2133392557 creator A5022477381 @default.
- W2133392557 creator A5026940043 @default.
- W2133392557 creator A5030804401 @default.
- W2133392557 creator A5038626811 @default.
- W2133392557 creator A5051522561 @default.
- W2133392557 creator A5054927262 @default.
- W2133392557 date "2008-01-01" @default.
- W2133392557 modified "2023-09-25" @default.
- W2133392557 title "Characterization of the Human Cytomegalovirus gH/gL/UL128-131 Complex That Mediates Entry into Epithelial and Endothelial Cells" @default.
- W2133392557 cites W1554718983 @default.
- W2133392557 cites W1576123222 @default.
- W2133392557 cites W1596206099 @default.
- W2133392557 cites W1596555978 @default.
- W2133392557 cites W1597998272 @default.
- W2133392557 cites W1638089104 @default.
- W2133392557 cites W1708005027 @default.
- W2133392557 cites W1965583223 @default.
- W2133392557 cites W1983955358 @default.
- W2133392557 cites W1988359861 @default.
- W2133392557 cites W1996688582 @default.
- W2133392557 cites W1998767391 @default.
- W2133392557 cites W2018011972 @default.
- W2133392557 cites W2018850937 @default.
- W2133392557 cites W2029345949 @default.
- W2133392557 cites W2031208709 @default.
- W2133392557 cites W2039607311 @default.
- W2133392557 cites W2042885383 @default.
- W2133392557 cites W2050738479 @default.
- W2133392557 cites W2061757869 @default.
- W2133392557 cites W2064416098 @default.
- W2133392557 cites W2065505211 @default.
- W2133392557 cites W2070907961 @default.
- W2133392557 cites W2075517421 @default.
- W2133392557 cites W2075921029 @default.
- W2133392557 cites W2080451831 @default.
- W2133392557 cites W2081761682 @default.
- W2133392557 cites W2089333797 @default.
- W2133392557 cites W2096963698 @default.
- W2133392557 cites W2097882890 @default.
- W2133392557 cites W2100289444 @default.
- W2133392557 cites W2103010723 @default.
- W2133392557 cites W2105594368 @default.
- W2133392557 cites W2105928329 @default.
- W2133392557 cites W2106604059 @default.
- W2133392557 cites W2107489422 @default.
- W2133392557 cites W2107638886 @default.
- W2133392557 cites W2114890741 @default.
- W2133392557 cites W2115456405 @default.
- W2133392557 cites W2118937969 @default.
- W2133392557 cites W2130128083 @default.
- W2133392557 cites W2132056562 @default.
- W2133392557 cites W2132275721 @default.
- W2133392557 cites W2133533422 @default.
- W2133392557 cites W2134738800 @default.
- W2133392557 cites W2135751988 @default.
- W2133392557 cites W2140404757 @default.
- W2133392557 cites W2141401084 @default.
- W2133392557 cites W2142159505 @default.
- W2133392557 cites W2143612653 @default.
- W2133392557 cites W2144714494 @default.
- W2133392557 cites W2148652086 @default.
- W2133392557 cites W2149818029 @default.
- W2133392557 cites W2159702641 @default.
- W2133392557 cites W2160245647 @default.
- W2133392557 cites W2161539371 @default.
- W2133392557 cites W2162066451 @default.
- W2133392557 cites W2162561429 @default.
- W2133392557 cites W2162867040 @default.
- W2133392557 cites W2166673821 @default.
- W2133392557 cites W2170651190 @default.
- W2133392557 cites W2170669821 @default.
- W2133392557 cites W2170764608 @default.
- W2133392557 doi "https://doi.org/10.1128/jvi.01910-07" @default.
- W2133392557 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2224386" @default.
- W2133392557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17942555" @default.
- W2133392557 hasPublicationYear "2008" @default.
- W2133392557 type Work @default.
- W2133392557 sameAs 2133392557 @default.
- W2133392557 citedByCount "290" @default.
- W2133392557 countsByYear W21333925572012 @default.
- W2133392557 countsByYear W21333925572013 @default.
- W2133392557 countsByYear W21333925572014 @default.
- W2133392557 countsByYear W21333925572015 @default.
- W2133392557 countsByYear W21333925572016 @default.
- W2133392557 countsByYear W21333925572017 @default.
- W2133392557 countsByYear W21333925572018 @default.
- W2133392557 countsByYear W21333925572019 @default.
- W2133392557 countsByYear W21333925572020 @default.
- W2133392557 countsByYear W21333925572021 @default.
- W2133392557 countsByYear W21333925572022 @default.
- W2133392557 countsByYear W21333925572023 @default.
- W2133392557 crossrefType "journal-article" @default.
- W2133392557 hasAuthorship W2133392557A5014390186 @default.
- W2133392557 hasAuthorship W2133392557A5022477381 @default.
- W2133392557 hasAuthorship W2133392557A5026940043 @default.