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- W2133394087 endingPage "1947" @default.
- W2133394087 startingPage "1937" @default.
- W2133394087 abstract "The mammalian kidney, the metanephros, is a mesodermal organ classically regarded as arising from the intermediate mesoderm (IM). Indeed, both the ureteric bud (UB), which gives rise to the ureter and the collecting ducts, and the metanephric mesenchyme (MM), which forms the rest of the kidney, derive from the IM. Based on an understanding of the signalling molecules crucial for IM patterning and kidney morphogenesis, several studies have now generated UB or MM, or both, in vitro via the directed differentiation of human pluripotent stem cells. Although these results support the IM origin of the UB and the MM, they challenge the simplistic view of a common progenitor for these two populations, prompting a reanalysis of early patterning events within the IM. Here, we review our understanding of the origin of the UB and the MM in mouse, and discuss how this impacts on kidney regeneration strategies and furthers our understanding of human development." @default.
- W2133394087 created "2016-06-24" @default.
- W2133394087 creator A5025271675 @default.
- W2133394087 creator A5026506282 @default.
- W2133394087 date "2015-06-01" @default.
- W2133394087 modified "2023-09-23" @default.
- W2133394087 title "The origin of the mammalian kidney: implications for recreating the kidney <i>in vitro</i>" @default.
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