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- W2133408384 abstract "We all live at a given point in time and history, but we also construct our own history in our life (see Fig. 1). In humans, life history is long and complex, and quality of life (QOL) is a serious concern for those who live a long life. Aging is the life stage that immediately follows maturation. Almost all multicellular organisms, particularly in the animal kingdom, are the product of sexual reproduction, beginning with the fertilization of an egg by a sperm and followed by differentiation and development, which include many processes that are primarily determined genetically. Species-specific traits and developmental processes are coded in the deoxyribonucleic acid (DNA), or the genetic material, of each species. In contrast, the question of whether aging is programmed similar to development or whether it is solely a stochastic process is controversial [1,2]. Recent molecular genetic studies, however, have clearly demonstrated that there is a set of genes that play a role in controlling animal longevity [3,4]. Lifespan is thus determined, at least in part, by longevity genes, but these genes may also affect the aging process. During our long lifespan, humans are susceptible to various life-stage-specific diseases. Some diseases affect development and maturation, resulting in shortened lifespan, and some affect aging and/or senescence, causing deteriorative changes in organs and tissues. Both types of diseases are relevant to gerontology and geriatric medicine (Fig. 1) Although there are many diseases associated with aging, Acta Med. Nagasaki 56: 73-80" @default.
- W2133408384 created "2016-06-24" @default.
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- W2133408384 date "2012-01-01" @default.
- W2133408384 modified "2023-09-26" @default.
- W2133408384 title "Quest for a Long Life: Paradoxes and Essentials of Evolving Longevity" @default.
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- W2133408384 doi "https://doi.org/10.11343/amn.56.73" @default.
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