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- W2133428704 abstract "Abstract Dantrolene sodium (Dantrium) has antiarrhythmic activity in addition to its direct-acting skeletal muscle relaxant activity. Dantrolene sodium exerts its skeletal muscle relaxant action by reducing Ca2+ release for sarcoplasmic reticulum. The mechanism by which dantrolene sodium produces its antiarrhythmic effects is not well defined. The effects of dantrolene sodium on [3H]nitrendipine binding to rat cardiac plasma membranes were, therefore, investigated to determine whether the antiarrhythmic action involves an interaction with calcium channels. Whereas 1,4-dihydropyridines maximally inhibited [3H]nitrendipine binding with IC50 values less than 1 nM, verapamil and gallopamil (D 600) inhibited the binding not more than 70% with IC50 values at μM concentrations. Dantrolene sodium caused only minimal inhibition at concentrations up to 100 μM. Thus, the antiarrhythmic action of the drug probably involves a mechanism(s) other than an interaction with the nitrendipine binding site of the slow inward calcium channel." @default.
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- W2133428704 date "1985-11-01" @default.
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- W2133428704 title "Effect of dantrolene sodium on [3H]nitrendipine binding to rat cardiac plasma membranes" @default.
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- W2133428704 doi "https://doi.org/10.1111/j.2042-7158.1985.tb04981.x" @default.
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