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• W2133430201 abstract "A small group of core transcription factors, including Twist, Snail, Slug, and Sip1, control epithelial–mesenchymal transitions (EMTs) during both embryonic development and tumor metastasis. However, little is known about how these factors are coordinately regulated to mediate the requisite behavioral and fate changes. It was recently shown that a key mechanism for regulating Snail proteins is by modulating their stability. In this paper, we report that the stability of Twist is also regulated by the ubiquitin–proteasome system. We found that the same E3 ubiquitin ligase known to regulate Snail family proteins, Partner of paired (Ppa), also controlled Twist stability and did so in a manner dependent on the Twist WR-rich domain. Surprisingly, Ppa could also target the third core EMT regulatory factor Sip1 for proteasomal degradation. Together, these results indicate that despite the structural diversity of the core transcriptional regulatory factors implicated in EMT, a common mechanism has evolved for controlling their stability and therefore their function." @default.
• W2133430201 created "2016-06-24" @default.
• W2133430201 creator A5002805838 @default.
• W2133430201 creator A5014247073 @default.
• W2133430201 creator A5068422548 @default.
• W2133430201 date "2011-07-04" @default.
• W2133430201 modified "2023-10-18" @default.
• W2133430201 title "The F-box protein Ppa is a common regulator of core EMT factors Twist, Snail, Slug, and Sip1" @default.
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• W2133430201 doi "https://doi.org/10.1083/jcb.201012085" @default.
• W2133430201 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3135407" @default.
• W2133430201 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21727196" @default.
• W2133430201 hasPublicationYear "2011" @default.
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