Matches in SemOpenAlex for { <https://semopenalex.org/work/W2133443322> ?p ?o ?g. }
- W2133443322 abstract "Purpose: To develop ampicillin trihydrate-loaded chitosan nanoparticles by modified ionic gelation method and evaluate their antimicrobial activity. Methods: Ampicillin trihydrate-loaded chitosan nanoparticles were prepared by ionic gelation method with the aid of sonication. Parameters such as the zeta potential, polydispersity, particle size, entrapment efficiency and in vitro drug release of the nanoparticles were assessed for optimization. The antibacterial properties of the nanoparticle formulation were evaluated and compared with that of a commercial formulation (reference). Results: Scanning electron microscopy revealed that the nanoparticles were in the nanosize range but irregular in shape. Concentrations of 0.35 %w/v of chitosan and 0.40 %w/v sodium tripolyphosphate (TPP) and a sonication time of 20 min constituted the optimum conditions for the preparation of the nanoparticles. In vitro release data showed an initial burst followed by slow sustained drug release. The nanoparticles demonstrated superior antimicrobial activity to plain nanoparticles and the reference, due probably to the synergistic effect of chitosan and ampicillin trihydrate. Conclusion: Modified ionic gelation method can be utilized for the development of chitosan nanoparticles of ampicillin trihydrate. Polymer and crosslinking agent concentrations and sonication time are rate-limiting factors for the development of the optimized formulation. The chitosan nanoparticles developed would be capable of sustained delivery of ampicillin trihydrate.Keywords: Ampicillin trihydrate; Chitosan; Nanoparticles; Ionic gelation method; Antibacterial activity" @default.
- W2133443322 created "2016-06-24" @default.
- W2133443322 creator A5004740492 @default.
- W2133443322 creator A5019038309 @default.
- W2133443322 creator A5061691357 @default.
- W2133443322 date "2010-10-18" @default.
- W2133443322 modified "2023-10-16" @default.
- W2133443322 title "Formulation and Evaluation of Chitosan-Based Ampicillin Trihydrate Nanoparticles" @default.
- W2133443322 cites W1586799259 @default.
- W2133443322 cites W1992865052 @default.
- W2133443322 cites W2031423988 @default.
- W2133443322 cites W2070342688 @default.
- W2133443322 cites W2100225360 @default.
- W2133443322 cites W2115170320 @default.
- W2133443322 cites W2138281910 @default.
- W2133443322 cites W2151539488 @default.
- W2133443322 cites W2156636796 @default.
- W2133443322 cites W2523530498 @default.
- W2133443322 cites W2153283856 @default.
- W2133443322 doi "https://doi.org/10.4314/tjpr.v9i5.61061" @default.
- W2133443322 hasPublicationYear "2010" @default.
- W2133443322 type Work @default.
- W2133443322 sameAs 2133443322 @default.
- W2133443322 citedByCount "38" @default.
- W2133443322 countsByYear W21334433222013 @default.
- W2133443322 countsByYear W21334433222014 @default.
- W2133443322 countsByYear W21334433222015 @default.
- W2133443322 countsByYear W21334433222016 @default.
- W2133443322 countsByYear W21334433222017 @default.
- W2133443322 countsByYear W21334433222018 @default.
- W2133443322 countsByYear W21334433222019 @default.
- W2133443322 countsByYear W21334433222020 @default.
- W2133443322 countsByYear W21334433222021 @default.
- W2133443322 countsByYear W21334433222022 @default.
- W2133443322 countsByYear W21334433222023 @default.
- W2133443322 crossrefType "journal-article" @default.
- W2133443322 hasAuthorship W2133443322A5004740492 @default.
- W2133443322 hasAuthorship W2133443322A5019038309 @default.
- W2133443322 hasAuthorship W2133443322A5061691357 @default.
- W2133443322 hasBestOaLocation W21334433221 @default.
- W2133443322 hasConcept C104628117 @default.
- W2133443322 hasConcept C11432220 @default.
- W2133443322 hasConcept C127413603 @default.
- W2133443322 hasConcept C13965031 @default.
- W2133443322 hasConcept C145148216 @default.
- W2133443322 hasConcept C147789679 @default.
- W2133443322 hasConcept C155672457 @default.
- W2133443322 hasConcept C171250308 @default.
- W2133443322 hasConcept C178790620 @default.
- W2133443322 hasConcept C184651966 @default.
- W2133443322 hasConcept C185592680 @default.
- W2133443322 hasConcept C187428577 @default.
- W2133443322 hasConcept C187530423 @default.
- W2133443322 hasConcept C192562407 @default.
- W2133443322 hasConcept C2182769 @default.
- W2133443322 hasConcept C2776021129 @default.
- W2133443322 hasConcept C2779732960 @default.
- W2133443322 hasConcept C2780104969 @default.
- W2133443322 hasConcept C42360764 @default.
- W2133443322 hasConcept C43617362 @default.
- W2133443322 hasConcept C501593827 @default.
- W2133443322 hasConcept C523546767 @default.
- W2133443322 hasConcept C54355233 @default.
- W2133443322 hasConcept C55493867 @default.
- W2133443322 hasConcept C86181022 @default.
- W2133443322 hasConcept C86803240 @default.
- W2133443322 hasConceptScore W2133443322C104628117 @default.
- W2133443322 hasConceptScore W2133443322C11432220 @default.
- W2133443322 hasConceptScore W2133443322C127413603 @default.
- W2133443322 hasConceptScore W2133443322C13965031 @default.
- W2133443322 hasConceptScore W2133443322C145148216 @default.
- W2133443322 hasConceptScore W2133443322C147789679 @default.
- W2133443322 hasConceptScore W2133443322C155672457 @default.
- W2133443322 hasConceptScore W2133443322C171250308 @default.
- W2133443322 hasConceptScore W2133443322C178790620 @default.
- W2133443322 hasConceptScore W2133443322C184651966 @default.
- W2133443322 hasConceptScore W2133443322C185592680 @default.
- W2133443322 hasConceptScore W2133443322C187428577 @default.
- W2133443322 hasConceptScore W2133443322C187530423 @default.
- W2133443322 hasConceptScore W2133443322C192562407 @default.
- W2133443322 hasConceptScore W2133443322C2182769 @default.
- W2133443322 hasConceptScore W2133443322C2776021129 @default.
- W2133443322 hasConceptScore W2133443322C2779732960 @default.
- W2133443322 hasConceptScore W2133443322C2780104969 @default.
- W2133443322 hasConceptScore W2133443322C42360764 @default.
- W2133443322 hasConceptScore W2133443322C43617362 @default.
- W2133443322 hasConceptScore W2133443322C501593827 @default.
- W2133443322 hasConceptScore W2133443322C523546767 @default.
- W2133443322 hasConceptScore W2133443322C54355233 @default.
- W2133443322 hasConceptScore W2133443322C55493867 @default.
- W2133443322 hasConceptScore W2133443322C86181022 @default.
- W2133443322 hasConceptScore W2133443322C86803240 @default.
- W2133443322 hasIssue "5" @default.
- W2133443322 hasLocation W21334433221 @default.
- W2133443322 hasLocation W21334433222 @default.
- W2133443322 hasLocation W21334433223 @default.
- W2133443322 hasOpenAccess W2133443322 @default.
- W2133443322 hasPrimaryLocation W21334433221 @default.
- W2133443322 hasRelatedWork W1986449167 @default.
- W2133443322 hasRelatedWork W2010095187 @default.