Matches in SemOpenAlex for { <https://semopenalex.org/work/W2133447633> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2133447633 endingPage "41" @default.
- W2133447633 startingPage "31" @default.
- W2133447633 abstract "Pregnenolone (PREG) and L-theanine (LT) have shown ameliorative effects on various schizophrenia symptoms. This is the first study to evaluate the efficacy and safety of augmentation of antipsychotic treatment among patients with chronic schizophrenia or schizoaffective disorder with PREG-LT.Double-blind, placebo-controlled trial of PREG-LT or placebo augmentation was conducted for eight weeks with 40 chronic DSM-IV schizophrenia and schizoaffective disorder patients with suboptimal response to antipsychotics. Oral PREG (50 mg/day) with LT (400 mg/day) or placebo were added to a stable regimen of antipsychotic medication from March 2011 to October 2013. The participants were rated using the Scale for the Assessment of Negative Symptoms (SANS), the Hamilton Scale for Anxiety (HAM-A), and the Positive and Negative Syndrome Scale (PANSS) scales bi-weekly. The decrease of SANS and HAM-A scores were the co-primary outcomes. Secondary outcomes included assessments of general functioning and side effects.Negative symptoms such as blunted affect, alogia, and anhedonia (SANS) were found to be significantly improved with moderate effect sizes among patients who received PREG-LT, in comparison with the placebo group. Add-on PREG-LT also significantly associated with a reduction of anxiety scores such as anxious mood, tension, and cardiovascular symptoms (HAM-A), and elevation of general functioning (GAF). Positive symptoms, antipsychotic agents, concomitant drugs, and illness duration did not associate significantly with effect of PREG-LT augmentation. PREG-LT was well-tolerated.Pregnenolone with L-theanine augmentation may offer a new therapeutic strategy for treatment of negative and anxiety symptoms in schizophrenia and schizoaffective disorder. Further studies are warranted.clinicaltrials.gov Identifier: NCT01831986." @default.
- W2133447633 created "2016-06-24" @default.
- W2133447633 creator A5034305099 @default.
- W2133447633 creator A5063731007 @default.
- W2133447633 creator A5088156729 @default.
- W2133447633 date "2018-03-01" @default.
- W2133447633 modified "2023-10-03" @default.
- W2133447633 title "Add-On Pregnenolone with L-Theanine to Antipsychotic Therapy Relieves Negative and Anxiety Symptoms of Schizophrenia: An 8-Week, Randomized, Double-Blind, Placebo-Controlled Trial" @default.
- W2133447633 cites W1564311086 @default.
- W2133447633 cites W1963580478 @default.
- W2133447633 cites W1974559875 @default.
- W2133447633 cites W2004944354 @default.
- W2133447633 cites W2008981321 @default.
- W2133447633 cites W2011154018 @default.
- W2133447633 cites W2032306731 @default.
- W2133447633 cites W2038766523 @default.
- W2133447633 cites W2043821206 @default.
- W2133447633 cites W2055572857 @default.
- W2133447633 cites W2085360366 @default.
- W2133447633 cites W2085517462 @default.
- W2133447633 cites W2129040804 @default.
- W2133447633 cites W2140606211 @default.
- W2133447633 cites W2163693517 @default.
- W2133447633 cites W2170000130 @default.
- W2133447633 doi "https://doi.org/10.3371/csrp.kara.070415" @default.
- W2133447633 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26218236" @default.
- W2133447633 hasPublicationYear "2018" @default.
- W2133447633 type Work @default.
- W2133447633 sameAs 2133447633 @default.
- W2133447633 citedByCount "14" @default.
- W2133447633 countsByYear W21334476332016 @default.
- W2133447633 countsByYear W21334476332017 @default.
- W2133447633 countsByYear W21334476332018 @default.
- W2133447633 countsByYear W21334476332019 @default.
- W2133447633 countsByYear W21334476332020 @default.
- W2133447633 countsByYear W21334476332021 @default.
- W2133447633 countsByYear W21334476332022 @default.
- W2133447633 countsByYear W21334476332023 @default.
- W2133447633 crossrefType "journal-article" @default.
- W2133447633 hasAuthorship W2133447633A5034305099 @default.
- W2133447633 hasAuthorship W2133447633A5063731007 @default.
- W2133447633 hasAuthorship W2133447633A5088156729 @default.
- W2133447633 hasConcept C118552586 @default.
- W2133447633 hasConcept C126322002 @default.
- W2133447633 hasConcept C142724271 @default.
- W2133447633 hasConcept C15744967 @default.
- W2133447633 hasConcept C204787440 @default.
- W2133447633 hasConcept C27081682 @default.
- W2133447633 hasConcept C2776412080 @default.
- W2133447633 hasConcept C2776921671 @default.
- W2133447633 hasConcept C2777696351 @default.
- W2133447633 hasConcept C2778941446 @default.
- W2133447633 hasConcept C2779727114 @default.
- W2133447633 hasConcept C2780135775 @default.
- W2133447633 hasConcept C2780325297 @default.
- W2133447633 hasConcept C2780494398 @default.
- W2133447633 hasConcept C558461103 @default.
- W2133447633 hasConcept C71924100 @default.
- W2133447633 hasConceptScore W2133447633C118552586 @default.
- W2133447633 hasConceptScore W2133447633C126322002 @default.
- W2133447633 hasConceptScore W2133447633C142724271 @default.
- W2133447633 hasConceptScore W2133447633C15744967 @default.
- W2133447633 hasConceptScore W2133447633C204787440 @default.
- W2133447633 hasConceptScore W2133447633C27081682 @default.
- W2133447633 hasConceptScore W2133447633C2776412080 @default.
- W2133447633 hasConceptScore W2133447633C2776921671 @default.
- W2133447633 hasConceptScore W2133447633C2777696351 @default.
- W2133447633 hasConceptScore W2133447633C2778941446 @default.
- W2133447633 hasConceptScore W2133447633C2779727114 @default.
- W2133447633 hasConceptScore W2133447633C2780135775 @default.
- W2133447633 hasConceptScore W2133447633C2780325297 @default.
- W2133447633 hasConceptScore W2133447633C2780494398 @default.
- W2133447633 hasConceptScore W2133447633C558461103 @default.
- W2133447633 hasConceptScore W2133447633C71924100 @default.
- W2133447633 hasIssue "1" @default.
- W2133447633 hasLocation W21334476331 @default.
- W2133447633 hasLocation W21334476332 @default.
- W2133447633 hasOpenAccess W2133447633 @default.
- W2133447633 hasPrimaryLocation W21334476331 @default.
- W2133447633 hasRelatedWork W1990546965 @default.
- W2133447633 hasRelatedWork W2062768595 @default.
- W2133447633 hasRelatedWork W2088495147 @default.
- W2133447633 hasRelatedWork W2118787204 @default.
- W2133447633 hasRelatedWork W2120374229 @default.
- W2133447633 hasRelatedWork W2128552524 @default.
- W2133447633 hasRelatedWork W2133447633 @default.
- W2133447633 hasRelatedWork W2473116086 @default.
- W2133447633 hasRelatedWork W2474679401 @default.
- W2133447633 hasRelatedWork W2945165853 @default.
- W2133447633 hasVolume "12" @default.
- W2133447633 isParatext "false" @default.
- W2133447633 isRetracted "false" @default.
- W2133447633 magId "2133447633" @default.
- W2133447633 workType "article" @default.