Matches in SemOpenAlex for { <https://semopenalex.org/work/W2133447682> ?p ?o ?g. }
- W2133447682 endingPage "1010" @default.
- W2133447682 startingPage "1001" @default.
- W2133447682 abstract "Abstract Cells react to viral infection by exhibiting IFN-based innate immune responses and integrated stress responses, but little is known about the interrelationships between the two. In this study, we report a linkage between these two host-protective cellular mechanisms. We found that IFN regulatory factor (IRF)7, the master regulator of type I IFN gene expression, interacts with activating transcription factor (ATF)4, a key component of the integrated stress responses whose translation is induced by viral infection and various stresses. We have demonstrated that IRF7 upregulates ATF4 activity and expression, whereas ATF4 in return inhibits IRF7 activation, suggesting a cross-regulation between the IFN response and the cellular integrated stress response that controls host innate immune defense against viral infection." @default.
- W2133447682 created "2016-06-24" @default.
- W2133447682 creator A5013495602 @default.
- W2133447682 creator A5016045886 @default.
- W2133447682 creator A5030805785 @default.
- W2133447682 creator A5034886921 @default.
- W2133447682 creator A5069161881 @default.
- W2133447682 date "2011-01-15" @default.
- W2133447682 modified "2023-09-28" @default.
- W2133447682 title "Negative Regulation of IRF7 Activation by Activating Transcription Factor 4 Suggests a Cross-Regulation between the IFN Responses and the Cellular Integrated Stress Responses" @default.
- W2133447682 cites W1788133348 @default.
- W2133447682 cites W1954448313 @default.
- W2133447682 cites W1970154782 @default.
- W2133447682 cites W1980438612 @default.
- W2133447682 cites W1982120218 @default.
- W2133447682 cites W1986814377 @default.
- W2133447682 cites W1989752867 @default.
- W2133447682 cites W1989929798 @default.
- W2133447682 cites W1993332077 @default.
- W2133447682 cites W1995150169 @default.
- W2133447682 cites W1999053786 @default.
- W2133447682 cites W2000175632 @default.
- W2133447682 cites W2000329335 @default.
- W2133447682 cites W2000650606 @default.
- W2133447682 cites W2004897341 @default.
- W2133447682 cites W2005884645 @default.
- W2133447682 cites W2010057180 @default.
- W2133447682 cites W2010581370 @default.
- W2133447682 cites W2011678998 @default.
- W2133447682 cites W2013583348 @default.
- W2133447682 cites W2017161741 @default.
- W2133447682 cites W2031840176 @default.
- W2133447682 cites W2032064870 @default.
- W2133447682 cites W2033378839 @default.
- W2133447682 cites W2035692565 @default.
- W2133447682 cites W2036584139 @default.
- W2133447682 cites W2037908592 @default.
- W2133447682 cites W2038481055 @default.
- W2133447682 cites W2044330780 @default.
- W2133447682 cites W2048551040 @default.
- W2133447682 cites W2053631267 @default.
- W2133447682 cites W2056305383 @default.
- W2133447682 cites W2061169429 @default.
- W2133447682 cites W2062813693 @default.
- W2133447682 cites W2063082801 @default.
- W2133447682 cites W2063229389 @default.
- W2133447682 cites W2064627937 @default.
- W2133447682 cites W2066680385 @default.
- W2133447682 cites W2071670416 @default.
- W2133447682 cites W2073905027 @default.
- W2133447682 cites W2077291760 @default.
- W2133447682 cites W2078844752 @default.
- W2133447682 cites W2083796374 @default.
- W2133447682 cites W2084880831 @default.
- W2133447682 cites W2085459501 @default.
- W2133447682 cites W2087123554 @default.
- W2133447682 cites W2089077517 @default.
- W2133447682 cites W2090603241 @default.
- W2133447682 cites W2094591113 @default.
- W2133447682 cites W2095638095 @default.
- W2133447682 cites W2096372976 @default.
- W2133447682 cites W2098296304 @default.
- W2133447682 cites W2105005820 @default.
- W2133447682 cites W2110719003 @default.
- W2133447682 cites W2119003997 @default.
- W2133447682 cites W2125546678 @default.
- W2133447682 cites W2126530235 @default.
- W2133447682 cites W2127848114 @default.
- W2133447682 cites W2131632095 @default.
- W2133447682 cites W2131933513 @default.
- W2133447682 cites W2142368962 @default.
- W2133447682 cites W2144787399 @default.
- W2133447682 cites W2145221987 @default.
- W2133447682 cites W2146201900 @default.
- W2133447682 cites W2148240014 @default.
- W2133447682 cites W2160045547 @default.
- W2133447682 cites W2160063406 @default.
- W2133447682 cites W2166336087 @default.
- W2133447682 cites W2167383814 @default.
- W2133447682 cites W2169933147 @default.
- W2133447682 cites W2333247929 @default.
- W2133447682 cites W4248219898 @default.
- W2133447682 doi "https://doi.org/10.4049/jimmunol.1002240" @default.
- W2133447682 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3057134" @default.
- W2133447682 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21148039" @default.
- W2133447682 hasPublicationYear "2011" @default.
- W2133447682 type Work @default.
- W2133447682 sameAs 2133447682 @default.
- W2133447682 citedByCount "39" @default.
- W2133447682 countsByYear W21334476822012 @default.
- W2133447682 countsByYear W21334476822013 @default.
- W2133447682 countsByYear W21334476822014 @default.
- W2133447682 countsByYear W21334476822016 @default.
- W2133447682 countsByYear W21334476822017 @default.
- W2133447682 countsByYear W21334476822018 @default.
- W2133447682 countsByYear W21334476822019 @default.
- W2133447682 countsByYear W21334476822020 @default.
- W2133447682 countsByYear W21334476822021 @default.