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- W2133471946 abstract "Citric-acid-derived thermally cross-linked biodegradable elastomers (CABEs) have recently received significant attention in various biomedical applications, including tissue-engineering orthopedic devices, bioimaging and implant coatings. However, citric-acid-derived photo-cross-linked biodegradable elastomers are rarely reported. Herein, we report a novel photo-cross-linked biodegradable elastomer, referred to as poly(octamethylene maleate citrate) (POMC), which preserves pendant hydroxyl and carboxylic functionalities after cross-linking for the potential conjugation of biologically active molecules. Pre-POMC is a low-molecular-mass pre-polymer with an average molecular mass between 701 and 1291 Da. POMC networks are soft and elastic with an initial modulus of 0.07 to 1.3 MPa and an elongation-at-break between 38 and 382%. FT-IR-ATR results confirmed the successful surface immobilization of type-I collagen onto POMC films, which enhanced in vitro cellular attachment and proliferation. Photo-polymerized POMC films implanted subcutaneously into Sprague-Dawley rats demonstrated minimal in vivo inflammatory responses. The development of POMC enriches the family of citric-acid-derived biodegradable elastomers and expands the available biodegradable polymers for versatile needs in biomedical applications." @default.
- W2133471946 created "2016-06-24" @default.
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- W2133471946 date "2010-01-01" @default.
- W2133471946 modified "2023-10-02" @default.
- W2133471946 title "Citric-Acid-Derived Photo-Cross-Linked Biodegradable Elastomers" @default.
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- W2133471946 doi "https://doi.org/10.1163/092050609x12567178204169" @default.
- W2133471946 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2943534" @default.
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