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• W2133482368 abstract "Oocyte maturation, fertilization, and early embryonic development occur in the absence of gene transcription. Therefore, it is critical to understand at a global level the post-transcriptional events that are driving these transitions. Here we used a systems approach by combining polysome mRNA profiling and bioinformatics to identify RNA-binding motifs in mRNAs that either enter or exit the polysome pool during mouse oocyte maturation. Association of mRNA with the polysomes correlates with active translation. Using this strategy, we identified highly specific patterns of mRNA recruitment to the polysomes that are synchronized with the cell cycle. A large number of the mRNAs recovered with translating ribosomes contain motifs for the RNA-binding proteins DAZL (deleted in azoospermia-like) and CPEB (cytoplasmic polyadenylation element-binding protein). Although a Dazl role in early germ cell development is well established, no function has been described during oocyte-to-embryo transition. We demonstrate that CPEB1 regulates Dazl post-transcriptionally, and that DAZL is essential for meiotic maturation and embryonic cleavage. In the absence of DAZL synthesis, the meiotic spindle fails to form due to disorganization of meiotic microtubules. Therefore, Cpeb1 and Dazl function in a progressive, self-reinforcing pathway to promote oocyte maturation and early embryonic development." @default.
• W2133482368 created "2016-06-24" @default.
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• W2133482368 date "2011-04-01" @default.
• W2133482368 modified "2023-10-14" @default.
• W2133482368 title "Genome-wide analysis of translation reveals a critical role for deleted in azoospermia-like (<i>Dazl</i>) at the oocyte-to-zygote transition" @default.
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• W2133482368 doi "https://doi.org/10.1101/gad.2028911" @default.
• W2133482368 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3070937" @default.
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