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• W2133485607 abstract "<h3>Objective</h3> To determine the response of dysplasia, carcinoma in situ (CIS), and T1 carcinoma of the oral cavity and larynx to photodynamic therapy with porfimer sodium. <h3>Design</h3> Prospective trial. <h3>Setting</h3> A National Cancer Institute–designated cancer institute. <h3>Patients</h3> Patients with primary or recurrent moderate to severe oral or laryngeal dysplasia, CIS, or T1N0 carcinoma. <h3>Intervention</h3> Porfimer sodium, 2 mg/kg of body weight, was injected intravenously 48 hours before treatment. Light at 630 nm for photosensitizer activation was delivered from an argon laser or diode laser using lens or cylindrical diffuser fibers. The light dose was 50 J/cm²for dysplasia and CIS and 75 J/cm²for carcinoma. <h3>Main Outcome Measures</h3> Response was evaluated at 1 week and at 1 month and then at 3-month intervals thereafter. Response options were complete (CR), partial (PR), and no (NR) response. Posttreatment biopsies were performed in all patients with persistent and recurrent visible lesions. <h3>Results</h3> Thirty patients were enrolled, and 26 were evaluable. Mean follow-up was 15 months (range, 7-52 months). Twenty-four patients had a CR, 1 had a PR, and 1 had NR. Three patients with oral dysplasia with an initial CR experienced recurrence in the treatment field. All the patients with NR, a PR, or recurrence after an initial CR underwent salvage treatment. Temporary morbidities included edema, pain, hoarseness, and skin phototoxicity. <h3>Conclusion</h3> Photodynamic therapy with porfimer sodium is an effective treatment alternative, with no permanent sequelae, for oral and laryngeal dysplasia and early carcinoma. <h3>Trial Registration</h3> clinicaltrials.gov Identifier:NCT00530088" @default.
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• W2133485607 date "2009-08-17" @default.
• W2133485607 modified "2023-09-30" @default.
• W2133485607 title "Photodynamic Therapy for Head and Neck Dysplasia and Cancer" @default.
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• W2133485607 doi "https://doi.org/10.1001/archoto.2009.98" @default.
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