FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2133485753> ?p ?o ?g. }

• W2133485753 endingPage "1379" @default.
• W2133485753 startingPage "1371" @default.
• W2133485753 abstract "Summary: Purpose: Iron accumulation in the brain has been associated with neurodegenerative disorders, including epilepsy. In our previous SAGE study, we showed that ferritin, an iron-storage protein, was one of the genes (Ferritin-H) that showed overexpression before the chronic epileptic phase. In this study we used ferritin as indicator for disturbed iron homeostasis to acquire insight into whether this could play a role in the pathogenesis of temporal lobe epilepsy. Methods: With immunocytochemistry, we studied the regional and cellular distribution of ferritin protein in an animal model for temporal lobe epilepsy in which spontaneous seizures develop a few weeks after electrically induced status epilepticus (SE). Results: Increased ferritin expression was observed in regions known to be vulnerable to cell death, mainly in reactive microglial cells of epileptic rats. Ferritin expression after SE was initially high, especially throughout the hippocampus, but decreased over time. In the chronic epileptic phase, it was still upregulated in regions where extensive cell loss occurs during the early acute and latent period. Within the parahippocampal region, the most persistent ferritin overexpression was present in microglial cells in layer III of the medial entorhinal area. The upregulation was most extensive in rats that had developed a progressive form of epilepsy with frequent seizures (approximately five to 10 seizures per day). Conclusions: The fact that ferritin upregulation is still present in specific limbic regions in chronic epileptic rats, when neuronal loss is absent or minimal, suggests a role of iron in the pathogenesis and progression of epilepsy." @default.
• W2133485753 created "2016-06-24" @default.
• W2133485753 creator A5002398450 @default.
• W2133485753 creator A5027533919 @default.
• W2133485753 creator A5031844504 @default.
• W2133485753 creator A5042934428 @default.
• W2133485753 creator A5071401229 @default.
• W2133485753 date "2005-09-01" @default.
• W2133485753 modified "2023-09-27" @default.
• W2133485753 title "Increased Expression of Ferritin, an Iron-storage Protein, in Specific Regions of the Parahippocampal Cortex of Epileptic Rats" @default.
• W2133485753 cites W1488034034 @default.
• W2133485753 cites W1508232918 @default.
• W2133485753 cites W1530284015 @default.
• W2133485753 cites W1589564633 @default.
• W2133485753 cites W1695332227 @default.
• W2133485753 cites W1982654686 @default.
• W2133485753 cites W1991745128 @default.
• W2133485753 cites W1999236279 @default.
• W2133485753 cites W2003066006 @default.
• W2133485753 cites W2019211967 @default.
• W2133485753 cites W2028790213 @default.
• W2133485753 cites W2031821545 @default.
• W2133485753 cites W2045738785 @default.
• W2133485753 cites W2047262638 @default.
• W2133485753 cites W2060156309 @default.
• W2133485753 cites W2061274901 @default.
• W2133485753 cites W2077740413 @default.
• W2133485753 cites W2087613580 @default.
• W2133485753 cites W2091173699 @default.
• W2133485753 cites W2097386446 @default.
• W2133485753 cites W2100539976 @default.
• W2133485753 cites W2101703484 @default.
• W2133485753 cites W2121541926 @default.
• W2133485753 cites W2122676711 @default.
• W2133485753 cites W2136799746 @default.
• W2133485753 cites W2164805147 @default.
• W2133485753 cites W2168379311 @default.
• W2133485753 cites W2313592706 @default.
• W2133485753 doi "https://doi.org/10.1111/j.1528-1167.2005.11505.x" @default.
• W2133485753 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16146431" @default.
• W2133485753 hasPublicationYear "2005" @default.
• W2133485753 type Work @default.
• W2133485753 sameAs 2133485753 @default.
• W2133485753 citedByCount "36" @default.
• W2133485753 countsByYear W21334857532012 @default.
• W2133485753 countsByYear W21334857532013 @default.
• W2133485753 countsByYear W21334857532014 @default.
• W2133485753 countsByYear W21334857532015 @default.
• W2133485753 countsByYear W21334857532017 @default.
• W2133485753 countsByYear W21334857532018 @default.
• W2133485753 countsByYear W21334857532020 @default.
• W2133485753 countsByYear W21334857532021 @default.
• W2133485753 countsByYear W21334857532022 @default.
• W2133485753 countsByYear W21334857532023 @default.
• W2133485753 crossrefType "journal-article" @default.
• W2133485753 hasAuthorship W2133485753A5002398450 @default.
• W2133485753 hasAuthorship W2133485753A5027533919 @default.
• W2133485753 hasAuthorship W2133485753A5031844504 @default.
• W2133485753 hasAuthorship W2133485753A5042934428 @default.
• W2133485753 hasAuthorship W2133485753A5071401229 @default.
• W2133485753 hasConcept C104317684 @default.
• W2133485753 hasConcept C127561419 @default.
• W2133485753 hasConcept C134018914 @default.
• W2133485753 hasConcept C142724271 @default.
• W2133485753 hasConcept C169760540 @default.
• W2133485753 hasConcept C2777341932 @default.
• W2133485753 hasConcept C2778186239 @default.
• W2133485753 hasConcept C2778319317 @default.
• W2133485753 hasConcept C2780715579 @default.
• W2133485753 hasConcept C2780942790 @default.
• W2133485753 hasConcept C2781099131 @default.
• W2133485753 hasConcept C2781161787 @default.
• W2133485753 hasConcept C55493867 @default.
• W2133485753 hasConcept C57236427 @default.
• W2133485753 hasConcept C71924100 @default.
• W2133485753 hasConcept C86803240 @default.
• W2133485753 hasConceptScore W2133485753C104317684 @default.
• W2133485753 hasConceptScore W2133485753C127561419 @default.
• W2133485753 hasConceptScore W2133485753C134018914 @default.
• W2133485753 hasConceptScore W2133485753C142724271 @default.
• W2133485753 hasConceptScore W2133485753C169760540 @default.
• W2133485753 hasConceptScore W2133485753C2777341932 @default.
• W2133485753 hasConceptScore W2133485753C2778186239 @default.
• W2133485753 hasConceptScore W2133485753C2778319317 @default.
• W2133485753 hasConceptScore W2133485753C2780715579 @default.
• W2133485753 hasConceptScore W2133485753C2780942790 @default.
• W2133485753 hasConceptScore W2133485753C2781099131 @default.
• W2133485753 hasConceptScore W2133485753C2781161787 @default.
• W2133485753 hasConceptScore W2133485753C55493867 @default.
• W2133485753 hasConceptScore W2133485753C57236427 @default.
• W2133485753 hasConceptScore W2133485753C71924100 @default.
• W2133485753 hasConceptScore W2133485753C86803240 @default.
• W2133485753 hasIssue "9" @default.
• W2133485753 hasLocation W21334857531 @default.
• W2133485753 hasLocation W21334857532 @default.
• W2133485753 hasOpenAccess W2133485753 @default.
• W2133485753 hasPrimaryLocation W21334857531 @default.
• W2133485753 hasRelatedWork W2000163104 @default.

• next