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• W2133492523 abstract "Abstract Post-traumatic inflammation is formed by molecular and cellular complex mechanisms whose final goal seems to be injured tissue regeneration. In the skin -an exterior organ of the body- mechanical or thermal injury induces the expression of different inflammatory phenotypes that resemble similar phenotypes expressed during embryo development. Particularly, molecular and cellular mechanisms involved in gastrulation return. This is a developmental phase that delineates the three embryonic germ layers: ectoderm, endoderm and mesoderm. Consequently, in the post-natal wounded skin, primitive functions related with the embryonic mesoderm, i.e. amniotic and yolk sac-derived, are expressed. Neurogenesis and hematogenesis stand out among the primitive function mechanisms involved. Interestingly, in these phases of the inflammatory response, whose molecular and cellular mechanisms are considered as traces of the early phases of the embryonic development, the mast cell, a cell that is supposedly inflammatory, plays a key role. The correlation that can be established between the embryonic and the inflammatory events suggests that the results obtained from the research regarding both great fields of knowledge must be interchangeable to obtain the maximum advantage." @default.
• W2133492523 created "2016-06-24" @default.
• W2133492523 creator A5011871761 @default.
• W2133492523 creator A5034104118 @default.
• W2133492523 creator A5048651154 @default.
• W2133492523 date "2010-09-14" @default.
• W2133492523 modified "2023-10-01" @default.
• W2133492523 title "Pathological axes of wound repair: Gastrulation revisited" @default.
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