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• W2133497912 abstract "textabstractThe neonatal respiratory distress syndrome (RDS) is characterized by immaturity of thelung, resulting in relative or absolute absence of pulmonary surfactant. Worldwide,neonates suffering from RDS have been treated successfully with exogenous surfactantpreparations. Currently, exogenous surfactant administration has been accepted as avaluable treatment for this syndrome. Nevertheless, many questions on exogenoussurfactant treatment remain unanswered.It has been observed that some infants did not respond to, or had only transientimprovement after, a single dose of exogenous surfactant. In other studies it wasobserved that better clinical outcome was seen in infants treated with either a higherdose of surfactant, or after repeated surfactant substitution. It was argued that exogenoussurfactant, after intratracheal substitution, was gradually inhibited by surfactant inhibitorspresent in the terminal lung units. By giving more exogenous surfactant this inhibitionwas abolished, resulting in improved lung function.The adult respiratory distress syndrome (ARDS) is characterized by acuterespiratory failure (ARF), and high-permeability edema fluid accumulating in thealveolar spaces. From experimental and clinical studies it is known that the pulmonarysurfactant system is also disturbed in this syndrome. Recently, a few patients sufferingfrom ARDS have been treated with exogenous surfactant. Although these case reportsare poorly documented, the best results were observed in patients treated with high dosesof exogenous surfactant.The work presented in this thesis focuses on the mechanisms of inhibition ofsurfactant function in different animal models of acute respiratory failure. To overcomethis inhibition, different treatment modalities with an exogenous surfactant preparationwill be presented." @default.
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• W2133497912 date "1993-04-28" @default.
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• W2133497912 title "Surfactant inhibition in acute respiratory failure : consequences for exogenous surfactant therapy" @default.
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