Matches in SemOpenAlex for { <https://semopenalex.org/work/W2133518897> ?p ?o ?g. }
- W2133518897 endingPage "1997" @default.
- W2133518897 startingPage "1984" @default.
- W2133518897 abstract "For the efficient trafficking of lysosomal proteins, the cationic-dependent and -independent mannose 6-phosphate receptors and sortilin must bind cargo in the Golgi apparatus, be packaged into clathrin-coated trafficking vesicles and traffic to the endosomes. Once in the endosomes, the receptors release their cargo into the endosomal lumen and recycle back to the Golgi for another round of trafficking, a process that requires retromer. In this study, we demonstrate that palmitoylation is required for the efficient retrograde trafficking of sortilin, and the cationic-independent mannose 6-phosphate as palmitoylation-deficient receptors remain trapped in the endosomes. Importantly, we also show that palmitoylation is required for receptor interaction with retromer as nonpalmitoylated receptor did not interact with retromer. In addition, we have identified DHHC-15 as the palmitoyltransferase responsible for this modification. In summary, we have shown the functional significance of palmitoylation in lysosomal receptor sorting and trafficking." @default.
- W2133518897 created "2016-06-24" @default.
- W2133518897 creator A5040292972 @default.
- W2133518897 creator A5049255592 @default.
- W2133518897 creator A5055767351 @default.
- W2133518897 creator A5065529659 @default.
- W2133518897 creator A5072274903 @default.
- W2133518897 creator A5078698621 @default.
- W2133518897 date "2008-10-10" @default.
- W2133518897 modified "2023-10-04" @default.
- W2133518897 title "Palmitoylation Controls Recycling in Lysosomal Sorting and Trafficking" @default.
- W2133518897 cites W1486951117 @default.
- W2133518897 cites W1607357356 @default.
- W2133518897 cites W1964834461 @default.
- W2133518897 cites W1980269923 @default.
- W2133518897 cites W1986415802 @default.
- W2133518897 cites W1988619763 @default.
- W2133518897 cites W1997957892 @default.
- W2133518897 cites W1998917031 @default.
- W2133518897 cites W1999056400 @default.
- W2133518897 cites W2009399134 @default.
- W2133518897 cites W2043835841 @default.
- W2133518897 cites W2046356716 @default.
- W2133518897 cites W2048869016 @default.
- W2133518897 cites W2055635996 @default.
- W2133518897 cites W2055965228 @default.
- W2133518897 cites W2062644850 @default.
- W2133518897 cites W2062819360 @default.
- W2133518897 cites W2063663222 @default.
- W2133518897 cites W2069717322 @default.
- W2133518897 cites W2078366752 @default.
- W2133518897 cites W2079911954 @default.
- W2133518897 cites W2086141702 @default.
- W2133518897 cites W2095381111 @default.
- W2133518897 cites W2098509515 @default.
- W2133518897 cites W2104063456 @default.
- W2133518897 cites W2105753898 @default.
- W2133518897 cites W2133324304 @default.
- W2133518897 cites W2134853947 @default.
- W2133518897 cites W2147042014 @default.
- W2133518897 cites W2148143437 @default.
- W2133518897 cites W2148838925 @default.
- W2133518897 cites W2150058209 @default.
- W2133518897 cites W2168205500 @default.
- W2133518897 cites W2412438333 @default.
- W2133518897 cites W269429565 @default.
- W2133518897 cites W4235424265 @default.
- W2133518897 doi "https://doi.org/10.1111/j.1600-0854.2008.00814.x" @default.
- W2133518897 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3500849" @default.
- W2133518897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18817523" @default.
- W2133518897 hasPublicationYear "2008" @default.
- W2133518897 type Work @default.
- W2133518897 sameAs 2133518897 @default.
- W2133518897 citedByCount "78" @default.
- W2133518897 countsByYear W21335188972012 @default.
- W2133518897 countsByYear W21335188972013 @default.
- W2133518897 countsByYear W21335188972014 @default.
- W2133518897 countsByYear W21335188972015 @default.
- W2133518897 countsByYear W21335188972016 @default.
- W2133518897 countsByYear W21335188972017 @default.
- W2133518897 countsByYear W21335188972018 @default.
- W2133518897 countsByYear W21335188972019 @default.
- W2133518897 countsByYear W21335188972020 @default.
- W2133518897 countsByYear W21335188972021 @default.
- W2133518897 countsByYear W21335188972022 @default.
- W2133518897 countsByYear W21335188972023 @default.
- W2133518897 crossrefType "journal-article" @default.
- W2133518897 hasAuthorship W2133518897A5040292972 @default.
- W2133518897 hasAuthorship W2133518897A5049255592 @default.
- W2133518897 hasAuthorship W2133518897A5055767351 @default.
- W2133518897 hasAuthorship W2133518897A5065529659 @default.
- W2133518897 hasAuthorship W2133518897A5072274903 @default.
- W2133518897 hasAuthorship W2133518897A5078698621 @default.
- W2133518897 hasBestOaLocation W21335188971 @default.
- W2133518897 hasConcept C102747710 @default.
- W2133518897 hasConcept C119062480 @default.
- W2133518897 hasConcept C144647389 @default.
- W2133518897 hasConcept C145458877 @default.
- W2133518897 hasConcept C146727910 @default.
- W2133518897 hasConcept C158617107 @default.
- W2133518897 hasConcept C170493617 @default.
- W2133518897 hasConcept C181199279 @default.
- W2133518897 hasConcept C2775960820 @default.
- W2133518897 hasConcept C2778350249 @default.
- W2133518897 hasConcept C2778822930 @default.
- W2133518897 hasConcept C2779201268 @default.
- W2133518897 hasConcept C2780216420 @default.
- W2133518897 hasConcept C28005876 @default.
- W2133518897 hasConcept C41625074 @default.
- W2133518897 hasConcept C55493867 @default.
- W2133518897 hasConcept C559089031 @default.
- W2133518897 hasConcept C57581600 @default.
- W2133518897 hasConcept C63162447 @default.
- W2133518897 hasConcept C79879829 @default.
- W2133518897 hasConcept C86803240 @default.
- W2133518897 hasConcept C95444343 @default.
- W2133518897 hasConceptScore W2133518897C102747710 @default.
- W2133518897 hasConceptScore W2133518897C119062480 @default.