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• W2133542906 endingPage "11478" @default.
• W2133542906 startingPage "11469" @default.
• W2133542906 abstract "The systemic injection of γ-hydroxybutyric acid (GHB) elicits spike and wave discharges (SWDs), the EEG hallmark of absence seizures, and represents a well established, widely used pharmacological model of this nonconvulsive epilepsy. Despite this experimental use of GHB, as well as its therapeutic use in narcolepsy and its increasing abuse, however, the precise cellular mechanisms underlying the different pharmacological actions of this drug are still unclear. Because sensory thalamic nuclei play a key role in the generation of SWDs and sleep rhythms, and because direct injection of GHB in the ventrobasal (VB) thalamus elicits SWDs, we investigated GHB effects on corticothalamic EPSCs and GABAergic IPSCs in VB thalamocortical (TC) neurons. GHB (250 μ m -10 m m ) reversibly decreased the amplitude of electrically evoked EPSCs and GABA A IPSCs via activation of GABA B receptors; however, ∼60% of the IPSCs were insensitive to low (250 μ m -1.0 m m ) GHB concentrations. The putative GHB receptor antagonist NSC 382 applied alone had a number of unspecific effects, whereas it either had no action on, or further increased, the GHB-elicited effects on synaptic currents. Low GHB concentrations (250 μ m ) were also effective in increasing absence-like intrathalamic oscillations evoked by cortical afferent stimulation. These results indicate that low concentrations of GHB, similar to the brain concentrations that evoke SWDs in vivo , differentially affect excitatory and inhibitory synaptic currents in TC neurons and promote absence-like intrathalamic oscillations. Furthermore, the present data strengthen previous suggestions on the GHB mechanism of sleep promotion and will help focus future studies on the cellular mechanisms underlying its abuse." @default.
• W2133542906 created "2016-06-24" @default.
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• W2133542906 date "2003-12-10" @default.
• W2133542906 modified "2023-10-16" @default.
• W2133542906 title "Pathway-Specific Action of γ-Hydroxybutyric Acid in Sensory Thalamus and Its Relevance to Absence Seizures" @default.
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• W2133542906 doi "https://doi.org/10.1523/jneurosci.23-36-11469.2003" @default.
• W2133542906 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6740512" @default.
• W2133542906 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14673012" @default.
• W2133542906 hasPublicationYear "2003" @default.
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