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- W2133554741 abstract "In order to develop novel and orally active phosphodiesterase (PDE) 4 inhibitors, random screening was performed using our chemical library to find YM-10335 possessing the 1,8-naphthyridin-2(1H)-one skeleton which is a completely different structure from rolipram. In this report, the syntheses and structure–activity relationships of the YM-10335 derivatives were described. Some compounds showed selective inhibitory activities for PDE 4 derived from human peripheral blood cells and no effect on the other PDE types (1, 2, 3, 5). The inhibition of the tumor necrosis factor-alpha (TNF-α) release in vitro and the carrageenan-induced pleurisy in rats were also described." @default.
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- W2133554741 date "2002-01-01" @default.
- W2133554741 modified "2023-10-18" @default.
- W2133554741 title "Synthetic Studies on Selective Type 4 Phosphodiesterase (PDE 4) Inhibitors. 1. Structure-Activity Relationships and Pharmacological Evaluation of 1,8-Naphthyridin-2(1H)-one Derivatives." @default.
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- W2133554741 doi "https://doi.org/10.1248/cpb.50.1050" @default.
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