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• W2133567701 abstract "A central question in immunology is the origin of long-lived T cell memory that confers protection against recurrent infection. The differentiation of naïve T cell receptor transgenic CD8+ cells into effector cytotoxic T lymphocytes (CTLs) and memory CD8+ cells was studied. Memory CD8+ cells that were generated after strong antigenic stimulation were the progeny of cytotoxic effectors and retained antigen-specific cytolytic activity 10 weeks after adoptive transfer to antigen-free recipient mice. Thus, potential vaccines based on CTL memory will require the differentiation of naïve cells into post-effector memory T cells." @default.
• W2133567701 created "2016-06-24" @default.
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• W2133567701 date "1999-03-12" @default.
• W2133567701 modified "2023-10-18" @default.
• W2133567701 title "Linear Differentiation of Cytotoxic Effectors into Memory T Lymphocytes" @default.
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• W2133567701 doi "https://doi.org/10.1126/science.283.5408.1745" @default.
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