FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2133569968> ?p ?o ?g. }

• W2133569968 abstract "We studied a patient with food-induced, ACTH-independent, Cushing's syndrome and a unilateral adrenocortical adenoma. In vivo cortisol secretion was stimulated by mixed, glucidic, lipidic, or proteic meals. Plasma ACTH levels were undetectable, but iv injection of ACTH stimulated cortisol secretion. Unilateral adrenalectomy was followed by hypocortisolism with loss of steroidogenic responses to both food and ACTH. In vitro, cortisol secretion by isolated tumor cells was stimulated by the gut hormone gastric inhibitory polypeptide (GIP) and ACTH, but not by another gut hormone, glucagon-like peptide-1 (GLP-1). Both peptides stimulated the production of cAMP but not of inositol 1,4,5-trisphosphate. In quiescent cells, GIP and ACTH stimulated [3H]thymidine incorporation and p42-p44 mitogen-activated protein kinase activity. GIP receptor messenger ribonucleic acid (RNA), assessed by RT-PCR, was highly expressed in the tumor, whereas it was undetectable in the adjacent hypotrophic adrenal tissue, in two adrenal tumors responsible for food-independent Cushing's syndrome, and in two hyperplastic adrenals associated with ACTH hypersecretion. In situ hybridization demonstrated that expression of GIP receptor RNA was confined to the adrenocortical tumor cells. Low levels of ACTH receptor messenger RNA were also detectable in the tumor. We conclude that abnormal expression of the GIP receptor allows adrenocortical cells to respond to food intake with an increase in cAMP that may participate in the stimulation of both cortisol secretion and proliferation of the tumor cells." @default.
• W2133569968 created "2016-06-24" @default.
• W2133569968 creator A5010322165 @default.
• W2133569968 creator A5015154592 @default.
• W2133569968 creator A5016652365 @default.
• W2133569968 creator A5017485807 @default.
• W2133569968 creator A5020865216 @default.
• W2133569968 creator A5021500862 @default.
• W2133569968 creator A5031795333 @default.
• W2133569968 creator A5040640339 @default.
• W2133569968 creator A5063024984 @default.
• W2133569968 creator A5067246679 @default.
• W2133569968 creator A5079148010 @default.
• W2133569968 date "1998-09-01" @default.
• W2133569968 modified "2023-09-25" @default.
• W2133569968 title "Cushing’s Syndrome due to a Gastric Inhibitory Polypeptide-Dependent Adrenal Adenoma: Insights into Hormonal Control of Adrenocortical Tumorigenesis1" @default.
• W2133569968 cites W1965963242 @default.
• W2133569968 cites W1976849281 @default.
• W2133569968 cites W1979420492 @default.
• W2133569968 cites W1982059853 @default.
• W2133569968 cites W1985317756 @default.
• W2133569968 cites W1990401009 @default.
• W2133569968 cites W1992965538 @default.
• W2133569968 cites W1995819749 @default.
• W2133569968 cites W2006910692 @default.
• W2133569968 cites W2011726766 @default.
• W2133569968 cites W2031588343 @default.
• W2133569968 cites W2041568753 @default.
• W2133569968 cites W2041604117 @default.
• W2133569968 cites W2059459109 @default.
• W2133569968 cites W2062025318 @default.
• W2133569968 cites W2065940035 @default.
• W2133569968 cites W2082030258 @default.
• W2133569968 cites W2088053118 @default.
• W2133569968 cites W2104723919 @default.
• W2133569968 cites W2115778460 @default.
• W2133569968 cites W2157210960 @default.
• W2133569968 cites W2320000533 @default.
• W2133569968 cites W2332386539 @default.
• W2133569968 cites W2336931002 @default.
• W2133569968 cites W2337777109 @default.
• W2133569968 cites W4294216491 @default.
• W2133569968 doi "https://doi.org/10.1210/jcem.83.9.5140" @default.
• W2133569968 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9745416" @default.
• W2133569968 hasPublicationYear "1998" @default.
• W2133569968 type Work @default.
• W2133569968 sameAs 2133569968 @default.
• W2133569968 citedByCount "25" @default.
• W2133569968 countsByYear W21335699682013 @default.
• W2133569968 countsByYear W21335699682015 @default.
• W2133569968 countsByYear W21335699682019 @default.
• W2133569968 crossrefType "journal-article" @default.
• W2133569968 hasAuthorship W2133569968A5010322165 @default.
• W2133569968 hasAuthorship W2133569968A5015154592 @default.
• W2133569968 hasAuthorship W2133569968A5016652365 @default.
• W2133569968 hasAuthorship W2133569968A5017485807 @default.
• W2133569968 hasAuthorship W2133569968A5020865216 @default.
• W2133569968 hasAuthorship W2133569968A5021500862 @default.
• W2133569968 hasAuthorship W2133569968A5031795333 @default.
• W2133569968 hasAuthorship W2133569968A5040640339 @default.
• W2133569968 hasAuthorship W2133569968A5063024984 @default.
• W2133569968 hasAuthorship W2133569968A5067246679 @default.
• W2133569968 hasAuthorship W2133569968A5079148010 @default.
• W2133569968 hasBestOaLocation W21335699681 @default.
• W2133569968 hasConcept C126322002 @default.
• W2133569968 hasConcept C134018914 @default.
• W2133569968 hasConcept C170493617 @default.
• W2133569968 hasConcept C177865409 @default.
• W2133569968 hasConcept C2776129832 @default.
• W2133569968 hasConcept C2777428134 @default.
• W2133569968 hasConcept C2777977426 @default.
• W2133569968 hasConcept C2778563252 @default.
• W2133569968 hasConcept C2778674399 @default.
• W2133569968 hasConcept C2778914232 @default.
• W2133569968 hasConcept C2780546910 @default.
• W2133569968 hasConcept C71315377 @default.
• W2133569968 hasConcept C71924100 @default.
• W2133569968 hasConcept C86803240 @default.
• W2133569968 hasConceptScore W2133569968C126322002 @default.
• W2133569968 hasConceptScore W2133569968C134018914 @default.
• W2133569968 hasConceptScore W2133569968C170493617 @default.
• W2133569968 hasConceptScore W2133569968C177865409 @default.
• W2133569968 hasConceptScore W2133569968C2776129832 @default.
• W2133569968 hasConceptScore W2133569968C2777428134 @default.
• W2133569968 hasConceptScore W2133569968C2777977426 @default.
• W2133569968 hasConceptScore W2133569968C2778563252 @default.
• W2133569968 hasConceptScore W2133569968C2778674399 @default.
• W2133569968 hasConceptScore W2133569968C2778914232 @default.
• W2133569968 hasConceptScore W2133569968C2780546910 @default.
• W2133569968 hasConceptScore W2133569968C71315377 @default.
• W2133569968 hasConceptScore W2133569968C71924100 @default.
• W2133569968 hasConceptScore W2133569968C86803240 @default.
• W2133569968 hasLocation W21335699681 @default.
• W2133569968 hasLocation W21335699682 @default.
• W2133569968 hasOpenAccess W2133569968 @default.
• W2133569968 hasPrimaryLocation W21335699681 @default.
• W2133569968 hasRelatedWork W1969371985 @default.
• W2133569968 hasRelatedWork W1988109236 @default.
• W2133569968 hasRelatedWork W2095350879 @default.
• W2133569968 hasRelatedWork W2115446572 @default.

• next