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- W2133588004 abstract "Due to the emergency of multidrug-resistant strains of Mycobacterium tuberculosis, is necessary the evaluation of new compounds.Tedizolid, a novel oxazolidinone, and ACH-702, a new isothiazoloquinolone, were tested against M. tuberculosis infected THP-1 macrophages. These two compounds significantly decreased the number of intracellular mycobacteria at 0.25X, 1X, 4X and 16X the MIC value. The drugs were tested either in nanoparticules or in free solution.Tedizolid and ACH-702 have a good intracellular killing activity comparable to that of rifampin or moxifloxacin." @default.
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- W2133588004 date "2014-01-01" @default.
- W2133588004 modified "2023-10-14" @default.
- W2133588004 title "Intracellular activity of tedizolid phosphate and ACH-702 versus Mycobacterium tuberculosis infected macrophages" @default.
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- W2133588004 doi "https://doi.org/10.1186/1476-0711-13-13" @default.
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