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- W2133591195 abstract "A new simple, accurate, rapid and precise gradient High Performance Liquid Chromatographic (HPLC ) method was developed and validate d for simultaneous estimation of Ofloxaccin and satranidazole in combined dosage form. The method employs waters HPLC system on Hypersil B DS C 18 Column (250 mm X 4.6 mm, 5 µ), with a flow rate of 1.0 ml / min with a load of 10 µl. Water + OPA (Ortho Phosphoric A cid) having pH 5.0 and acetonitrile was used as a mobile phase i n the composition of 60:40 % v/v . The detection was carried out by PDA detector at 295 nm . Linearity ranges for Ofloxaccin and satranidazole were 100 – 300 μ g / ml for Ofloxaccin , 150 – 450 μ g / ml for satranidazole respectively. Retention time of Ofloxaccin and Satranidazole were found to be 2.881 min utes , 4.042 min utes respectively. Percent recovery study values of Ofloxaccin and Satranidazole were found to be 99.003 – 100.5 % and 98.6 – 100.4 % respectively . T his newly developed method was successfully utilized for the quantitative estimation of Ofloxaccin and Satranid azole in combined" @default.
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- W2133591195 date "2013-09-09" @default.
- W2133591195 modified "2023-09-26" @default.
- W2133591195 title "METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF OFLOXACCIN AND SATRANIDAZOLE BY USING RP-HPLC" @default.
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- W2133591195 doi "https://doi.org/10.7897/2230-8407.04848" @default.
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