FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2133608170> ?p ?o ?g. }

• W2133608170 endingPage "172" @default.
• W2133608170 startingPage "165" @default.
• W2133608170 abstract "Amphiphilic and fluorescent covalently labelled core-shell nanoparticles based on poly(methyl methacrylate) (PMMA), were prepared by random copolymerisation of N-Vinyl carbazole (NVC) with MMA, initiated on polysaccharidic radicals, yielding diblock copolymers of either dextran-P(MMA-NVC) (Nanodex* particles), or heparin-P(MMA-NVC) (Nanohep* particles). Nanoparticles made from random copolymers of P(MMA-NVC) (PMMA*) were used as controls. The interactions between particles and a J774A1 murine macrophage-like cell line were quantified by direct measurement of the cell-associated fluorescence. The association with the cells occurred within 30 min. Nanodex* and Nanohep* showed considerably less association than the control PMMA* particles. Some of the particle uptake could be attributed to phagocytosis, but more than 50% of the cell-associated fluorescence persisted at low temperature or in the presence of cytochalasin B. The results suggest that both the adsorption and the internalisation processes can be inhibited by the presence of the polysaccharide chains. In conclusion, these results confirm that nanoparticles prepared with heparin or dextran chains on their surface, probably in a brush-like configuration, show stealth properties in vitro as had previously been observed in vivo. If this biomimetic approach can also be applied to biodegradable polymers, these systems would provide at least an alternative to PEG-modified particles as long-circulating drug carriers systems or imaging agents." @default.
• W2133608170 created "2016-06-24" @default.
• W2133608170 creator A5020905864 @default.
• W2133608170 creator A5027163060 @default.
• W2133608170 creator A5035704254 @default.
• W2133608170 creator A5059660618 @default.
• W2133608170 creator A5073637710 @default.
• W2133608170 date "2000-01-01" @default.
• W2133608170 modified "2023-10-18" @default.
• W2133608170 title "Reduction of the Uptake by a Macrophagic Cell Line of Nanoparticles Bearing Heparin or Dextran Covalently Bound to Poly(methyl methacrylate)" @default.
• W2133608170 cites W1495905026 @default.
• W2133608170 cites W1967838912 @default.
• W2133608170 cites W1987625413 @default.
• W2133608170 cites W1990463170 @default.
• W2133608170 cites W2000076998 @default.
• W2133608170 cites W2013577748 @default.
• W2133608170 cites W2023619846 @default.
• W2133608170 cites W2029749273 @default.
• W2133608170 cites W2030822319 @default.
• W2133608170 cites W2032508910 @default.
• W2133608170 cites W2041872486 @default.
• W2133608170 cites W2043181258 @default.
• W2133608170 cites W2069685592 @default.
• W2133608170 cites W2073784254 @default.
• W2133608170 cites W2084915032 @default.
• W2133608170 cites W2114918609 @default.
• W2133608170 cites W2118192610 @default.
• W2133608170 cites W2131465617 @default.
• W2133608170 cites W2148075784 @default.
• W2133608170 cites W2333038355 @default.
• W2133608170 cites W2419257755 @default.
• W2133608170 cites W262582492 @default.
• W2133608170 doi "https://doi.org/10.3109/10611860008996862" @default.
• W2133608170 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10938526" @default.
• W2133608170 hasPublicationYear "2000" @default.
• W2133608170 type Work @default.
• W2133608170 sameAs 2133608170 @default.
• W2133608170 citedByCount "47" @default.
• W2133608170 countsByYear W21336081702012 @default.
• W2133608170 countsByYear W21336081702013 @default.
• W2133608170 countsByYear W21336081702014 @default.
• W2133608170 countsByYear W21336081702015 @default.
• W2133608170 countsByYear W21336081702016 @default.
• W2133608170 countsByYear W21336081702018 @default.
• W2133608170 countsByYear W21336081702019 @default.
• W2133608170 countsByYear W21336081702020 @default.
• W2133608170 crossrefType "journal-article" @default.
• W2133608170 hasAuthorship W2133608170A5020905864 @default.
• W2133608170 hasAuthorship W2133608170A5027163060 @default.
• W2133608170 hasAuthorship W2133608170A5035704254 @default.
• W2133608170 hasAuthorship W2133608170A5059660618 @default.
• W2133608170 hasAuthorship W2133608170A5073637710 @default.
• W2133608170 hasConcept C12554922 @default.
• W2133608170 hasConcept C127413603 @default.
• W2133608170 hasConcept C132050475 @default.
• W2133608170 hasConcept C155672457 @default.
• W2133608170 hasConcept C15920480 @default.
• W2133608170 hasConcept C171250308 @default.
• W2133608170 hasConcept C178790620 @default.
• W2133608170 hasConcept C180577832 @default.
• W2133608170 hasConcept C185592680 @default.
• W2133608170 hasConcept C188027245 @default.
• W2133608170 hasConcept C192562407 @default.
• W2133608170 hasConcept C2777339698 @default.
• W2133608170 hasConcept C2777935641 @default.
• W2133608170 hasConcept C2780718992 @default.
• W2133608170 hasConcept C42360764 @default.
• W2133608170 hasConcept C521977710 @default.
• W2133608170 hasConcept C86803240 @default.
• W2133608170 hasConceptScore W2133608170C12554922 @default.
• W2133608170 hasConceptScore W2133608170C127413603 @default.
• W2133608170 hasConceptScore W2133608170C132050475 @default.
• W2133608170 hasConceptScore W2133608170C155672457 @default.
• W2133608170 hasConceptScore W2133608170C15920480 @default.
• W2133608170 hasConceptScore W2133608170C171250308 @default.
• W2133608170 hasConceptScore W2133608170C178790620 @default.
• W2133608170 hasConceptScore W2133608170C180577832 @default.
• W2133608170 hasConceptScore W2133608170C185592680 @default.
• W2133608170 hasConceptScore W2133608170C188027245 @default.
• W2133608170 hasConceptScore W2133608170C192562407 @default.
• W2133608170 hasConceptScore W2133608170C2777339698 @default.
• W2133608170 hasConceptScore W2133608170C2777935641 @default.
• W2133608170 hasConceptScore W2133608170C2780718992 @default.
• W2133608170 hasConceptScore W2133608170C42360764 @default.
• W2133608170 hasConceptScore W2133608170C521977710 @default.
• W2133608170 hasConceptScore W2133608170C86803240 @default.
• W2133608170 hasIssue "3" @default.
• W2133608170 hasLocation W21336081701 @default.
• W2133608170 hasLocation W21336081702 @default.
• W2133608170 hasOpenAccess W2133608170 @default.
• W2133608170 hasPrimaryLocation W21336081701 @default.
• W2133608170 hasRelatedWork W1978444047 @default.
• W2133608170 hasRelatedWork W1999566194 @default.
• W2133608170 hasRelatedWork W2013669775 @default.
• W2133608170 hasRelatedWork W2021634762 @default.
• W2133608170 hasRelatedWork W2028685256 @default.
• W2133608170 hasRelatedWork W2036942437 @default.
• W2133608170 hasRelatedWork W2041686704 @default.

• next