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- W2133615592 abstract "Three-dimensional organization of the genome is important for regulation of gene expression and maintenance of genomic stability. It also defines, and is defined by, contacts between different chromosomal loci. Interactions between loci positioned on different chromosomes, i.e. trans interactions are one type of such contacts. Here, we describe a case of inducible trans interaction in chromosomes of the budding yeast S. cerevisiae. Special DNA sequences, inserted in two ectopic chromosomal loci positioned in trans, pair with one another in an inducible manner. The spatial proximity diagnostic of pairing is observable by both chromosome capture analysis (3C) and epifluorescence microscopy in whole cells. Protein synthesis de novo appears to be required for this process. The three-dimensional organization of the yeast nucleus imposes a constraint on such pairing, presumably by dictating the probability with which the two sequences collide with one another." @default.
- W2133615592 created "2016-06-24" @default.
- W2133615592 creator A5005513313 @default.
- W2133615592 creator A5048444476 @default.
- W2133615592 creator A5078844801 @default.
- W2133615592 date "2013-09-30" @default.
- W2133615592 modified "2023-09-26" @default.
- W2133615592 title "Dynamic Trans Interactions in Yeast Chromosomes" @default.
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- W2133615592 doi "https://doi.org/10.1371/journal.pone.0075895" @default.
- W2133615592 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3786970" @default.
- W2133615592 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24098740" @default.
- W2133615592 hasPublicationYear "2013" @default.
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