FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2133623974> ?p ?o ?g. }

• W2133623974 endingPage "259" @default.
• W2133623974 startingPage "251" @default.
• W2133623974 abstract "The EP2 and EP4 prostanoid receptors are G-protein-coupled receptors whose activation by their endogenous ligand, prostaglandin (PG) E2, stimulates the formation of intracellular cAMP. We have previously reported that the stimulation of cAMP formation in EP4-expressing cells is significantly less than in EP2-expressing cells, despite nearly identical levels of receptor expression (J Biol Chem 277:2614-2619, 2002). In addition, a component of EP4 receptor signaling, but not of EP2 receptor signaling, was found to involve the activation of phosphatidylinositol 3-kinase (PI3K). In this study, we report that PGE2 stimulation of cells expressing either the EP2 or EP4 receptor results in the phosphorylation of the cAMP response element binding protein (CREB) at serine-133. Pretreatment of cells with N-[2-(4-bromocinnamylamino)ethyl]-5-isoquinoline (H-89), an inhibitor of protein kinase A (PKA), attenuated the PGE2-mediated phosphorylation of CREB in EP2-expressing cells, but not in EP4-expressing cells. Pretreatment of cells with wortmannin, an inhibitor of PI3K, had no effects on the PGE2-mediated phosphorylation of CREB in either EP2- or EP4-expressing cells, although it significantly increased the PGE2-mediated activation of PKA in EP4-expressing cells. However, combined pretreatment with H-89 and wortmannin blocked PGE2-mediated phosphorylation in EP2-expressing cells as well as in EP2-expressing cells. PGE2-mediated intracellular cAMP formation was not affected by pretreatment with wortmannin, or combined treatment with wortmannin and H-89, in either the EP2- or EP4-expressing cells. These findings suggest that PGE2 stimulation of EP4 receptors, but not EP2 receptors, results in the activation of a PI3K signaling pathway that inhibits the activity of PKA and that the PGE2-mediated phosphorylation of CREB by these receptors occurs through different signaling pathways" @default.
• W2133623974 created "2016-06-24" @default.
• W2133623974 creator A5044840358 @default.
• W2133623974 creator A5069663542 @default.
• W2133623974 creator A5089867564 @default.
• W2133623974 date "2005-04-26" @default.
• W2133623974 modified "2023-09-23" @default.
• W2133623974 title "Differential Regulation of Phosphorylation of the cAMP Response Element-Binding Protein after Activation of EP₂and EP₄Prostanoid Receptors by Prostaglandin E₂" @default.
• W2133623974 cites W1546944401 @default.
• W2133623974 cites W1911968642 @default.
• W2133623974 cites W1966890048 @default.
• W2133623974 cites W2009229814 @default.
• W2133623974 cites W2013293486 @default.
• W2133623974 cites W2030571587 @default.
• W2133623974 cites W2038084627 @default.
• W2133623974 cites W2053425043 @default.
• W2133623974 cites W2058034672 @default.
• W2133623974 cites W2059072734 @default.
• W2133623974 cites W2063322239 @default.
• W2133623974 cites W2069228549 @default.
• W2133623974 cites W2087744847 @default.
• W2133623974 cites W2087753442 @default.
• W2133623974 cites W2088359631 @default.
• W2133623974 cites W2136237753 @default.
• W2133623974 doi "https://doi.org/10.1124/mol.105.011833" @default.
• W2133623974 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15855407" @default.
• W2133623974 hasPublicationYear "2005" @default.
• W2133623974 type Work @default.
• W2133623974 sameAs 2133623974 @default.
• W2133623974 citedByCount "153" @default.
• W2133623974 countsByYear W21336239742012 @default.
• W2133623974 countsByYear W21336239742013 @default.
• W2133623974 countsByYear W21336239742014 @default.
• W2133623974 countsByYear W21336239742015 @default.
• W2133623974 countsByYear W21336239742016 @default.
• W2133623974 countsByYear W21336239742017 @default.
• W2133623974 countsByYear W21336239742018 @default.
• W2133623974 countsByYear W21336239742019 @default.
• W2133623974 countsByYear W21336239742020 @default.
• W2133623974 countsByYear W21336239742021 @default.
• W2133623974 countsByYear W21336239742022 @default.
• W2133623974 countsByYear W21336239742023 @default.
• W2133623974 crossrefType "journal-article" @default.
• W2133623974 hasAuthorship W2133623974A5044840358 @default.
• W2133623974 hasAuthorship W2133623974A5069663542 @default.
• W2133623974 hasAuthorship W2133623974A5089867564 @default.
• W2133623974 hasConcept C104317684 @default.
• W2133623974 hasConcept C11960822 @default.
• W2133623974 hasConcept C153911025 @default.
• W2133623974 hasConcept C1629964 @default.
• W2133623974 hasConcept C170493617 @default.
• W2133623974 hasConcept C178592051 @default.
• W2133623974 hasConcept C185592680 @default.
• W2133623974 hasConcept C2778266237 @default.
• W2133623974 hasConcept C2778308172 @default.
• W2133623974 hasConcept C2778938600 @default.
• W2133623974 hasConcept C55493867 @default.
• W2133623974 hasConcept C62478195 @default.
• W2133623974 hasConcept C75217442 @default.
• W2133623974 hasConcept C86339819 @default.
• W2133623974 hasConcept C86803240 @default.
• W2133623974 hasConcept C95444343 @default.
• W2133623974 hasConcept C97029542 @default.
• W2133623974 hasConceptScore W2133623974C104317684 @default.
• W2133623974 hasConceptScore W2133623974C11960822 @default.
• W2133623974 hasConceptScore W2133623974C153911025 @default.
• W2133623974 hasConceptScore W2133623974C1629964 @default.
• W2133623974 hasConceptScore W2133623974C170493617 @default.
• W2133623974 hasConceptScore W2133623974C178592051 @default.
• W2133623974 hasConceptScore W2133623974C185592680 @default.
• W2133623974 hasConceptScore W2133623974C2778266237 @default.
• W2133623974 hasConceptScore W2133623974C2778308172 @default.
• W2133623974 hasConceptScore W2133623974C2778938600 @default.
• W2133623974 hasConceptScore W2133623974C55493867 @default.
• W2133623974 hasConceptScore W2133623974C62478195 @default.
• W2133623974 hasConceptScore W2133623974C75217442 @default.
• W2133623974 hasConceptScore W2133623974C86339819 @default.
• W2133623974 hasConceptScore W2133623974C86803240 @default.
• W2133623974 hasConceptScore W2133623974C95444343 @default.
• W2133623974 hasConceptScore W2133623974C97029542 @default.
• W2133623974 hasIssue "1" @default.
• W2133623974 hasLocation W21336239741 @default.
• W2133623974 hasLocation W21336239742 @default.
• W2133623974 hasOpenAccess W2133623974 @default.
• W2133623974 hasPrimaryLocation W21336239741 @default.
• W2133623974 hasRelatedWork W1968684437 @default.
• W2133623974 hasRelatedWork W2013079253 @default.
• W2133623974 hasRelatedWork W2081580860 @default.
• W2133623974 hasRelatedWork W2115672440 @default.
• W2133623974 hasRelatedWork W2129746956 @default.
• W2133623974 hasRelatedWork W2133623974 @default.
• W2133623974 hasRelatedWork W2358905232 @default.
• W2133623974 hasRelatedWork W2518776124 @default.
• W2133623974 hasRelatedWork W371847375 @default.
• W2133623974 hasRelatedWork W4210774785 @default.
• W2133623974 hasVolume "68" @default.
• W2133623974 isParatext "false" @default.
• W2133623974 isRetracted "false" @default.

• next