Matches in SemOpenAlex for { <https://semopenalex.org/work/W2133624076> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2133624076 endingPage "123" @default.
- W2133624076 startingPage "115" @default.
- W2133624076 abstract "Smooth muscle myosin has two reactive thiols located near the C-terminal region of its motor domain, the “converter”, which rotates by ∼70° upon the transition from the “nucleotide-free” state to the “pre-power stroke” state. The incorporation rates of a thiol reagent, 5-(((2-iodoacetyl)amino)ethyl)aminonaphthalene-1-sulfonic acid (IAEDANS), into these thiols were greatly altered by adding ATP or changing the myosin conformation. Comparisons of the myosin structures in the pre-power stroke state and the nucleotide-free state explained why the reactivity of both thiols is especially sensitive to a conformational change around the converter, and thus can be used as a sensor of the rotation of the converter. Modeling of the myosin structure in the pre-power stroke state, in which the most reactive thiol, “SH1”, was selectively modified with IAEDANS, revealed that this label becomes an obstacle when the converter completely rotates toward its position in the pre-power stroke state, thus resulting in incomplete rotation of the converter. Therefore, we suggest that the limitation of the converter rotation by modification causes the as-yet unexplained phenomena of SH1-modified myosin, including the inhibition of 10S myosin formation and the losses in phosphorylation-dependent regulation of the basic and actin-activated Mg–ATPase activities of myosin." @default.
- W2133624076 created "2016-06-24" @default.
- W2133624076 creator A5025946910 @default.
- W2133624076 creator A5051657820 @default.
- W2133624076 date "2008-04-01" @default.
- W2133624076 modified "2023-10-11" @default.
- W2133624076 title "Thiol reactivity as a sensor of rotation of the converter in myosin" @default.
- W2133624076 cites W100430351 @default.
- W2133624076 cites W105237061 @default.
- W2133624076 cites W1480084192 @default.
- W2133624076 cites W1488122477 @default.
- W2133624076 cites W1503552203 @default.
- W2133624076 cites W1532525052 @default.
- W2133624076 cites W1538692246 @default.
- W2133624076 cites W1551049760 @default.
- W2133624076 cites W1569283491 @default.
- W2133624076 cites W1817791182 @default.
- W2133624076 cites W1881885108 @default.
- W2133624076 cites W1898941074 @default.
- W2133624076 cites W1906781755 @default.
- W2133624076 cites W1912633728 @default.
- W2133624076 cites W1958392984 @default.
- W2133624076 cites W1967906546 @default.
- W2133624076 cites W1978494059 @default.
- W2133624076 cites W1979952843 @default.
- W2133624076 cites W1988435430 @default.
- W2133624076 cites W1996513348 @default.
- W2133624076 cites W1998687037 @default.
- W2133624076 cites W2014719041 @default.
- W2133624076 cites W2022449264 @default.
- W2133624076 cites W2023439329 @default.
- W2133624076 cites W2034367448 @default.
- W2133624076 cites W2038253226 @default.
- W2133624076 cites W2044629144 @default.
- W2133624076 cites W2046167970 @default.
- W2133624076 cites W2047896716 @default.
- W2133624076 cites W2052869024 @default.
- W2133624076 cites W2069953906 @default.
- W2133624076 cites W2079922247 @default.
- W2133624076 cites W2092236849 @default.
- W2133624076 cites W2093695555 @default.
- W2133624076 cites W2097055994 @default.
- W2133624076 cites W2101191271 @default.
- W2133624076 cites W2120205493 @default.
- W2133624076 cites W2137765989 @default.
- W2133624076 cites W2154663686 @default.
- W2133624076 cites W2218720641 @default.
- W2133624076 cites W2346166802 @default.
- W2133624076 doi "https://doi.org/10.1016/j.bbrc.2007.11.148" @default.
- W2133624076 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18068118" @default.
- W2133624076 hasPublicationYear "2008" @default.
- W2133624076 type Work @default.
- W2133624076 sameAs 2133624076 @default.
- W2133624076 citedByCount "6" @default.
- W2133624076 countsByYear W21336240762012 @default.
- W2133624076 countsByYear W21336240762015 @default.
- W2133624076 countsByYear W21336240762018 @default.
- W2133624076 countsByYear W21336240762021 @default.
- W2133624076 countsByYear W21336240762023 @default.
- W2133624076 crossrefType "journal-article" @default.
- W2133624076 hasAuthorship W2133624076A5025946910 @default.
- W2133624076 hasAuthorship W2133624076A5051657820 @default.
- W2133624076 hasConcept C12554922 @default.
- W2133624076 hasConcept C185592680 @default.
- W2133624076 hasConcept C2781324293 @default.
- W2133624076 hasConcept C55493867 @default.
- W2133624076 hasConcept C6997183 @default.
- W2133624076 hasConcept C86803240 @default.
- W2133624076 hasConceptScore W2133624076C12554922 @default.
- W2133624076 hasConceptScore W2133624076C185592680 @default.
- W2133624076 hasConceptScore W2133624076C2781324293 @default.
- W2133624076 hasConceptScore W2133624076C55493867 @default.
- W2133624076 hasConceptScore W2133624076C6997183 @default.
- W2133624076 hasConceptScore W2133624076C86803240 @default.
- W2133624076 hasIssue "1" @default.
- W2133624076 hasLocation W21336240761 @default.
- W2133624076 hasLocation W21336240762 @default.
- W2133624076 hasOpenAccess W2133624076 @default.
- W2133624076 hasPrimaryLocation W21336240761 @default.
- W2133624076 hasRelatedWork W1531601525 @default.
- W2133624076 hasRelatedWork W2319480705 @default.
- W2133624076 hasRelatedWork W2384464875 @default.
- W2133624076 hasRelatedWork W2606230654 @default.
- W2133624076 hasRelatedWork W2607424097 @default.
- W2133624076 hasRelatedWork W2748952813 @default.
- W2133624076 hasRelatedWork W2899084033 @default.
- W2133624076 hasRelatedWork W2948807893 @default.
- W2133624076 hasRelatedWork W4289222729 @default.
- W2133624076 hasRelatedWork W2778153218 @default.
- W2133624076 hasVolume "369" @default.
- W2133624076 isParatext "false" @default.
- W2133624076 isRetracted "false" @default.
- W2133624076 magId "2133624076" @default.
- W2133624076 workType "article" @default.