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- W2133637743 abstract "Existing strategies for gene therapy in the treatment of Parkinson's disease include the delivery of genes encoding dopamine (DA)-synthesising enzymes, leading to localised production of DA in the striatum; genes encoding factors that protect nigral neurons against ongoing degeneration, such as glial cell line-derived neurotrophic factor; and genes encoding proteins that produce the inhibitory transmitter gamma-aminobutylic acid (GABA) in the subthalamic nucleus (STN), thus suppressing the hyperactive STN. Recombinant adeno-associated viral (rAAV) vectors, which are derived from non-pathogenic viruses, have been shown to be suitable for clinical trials. These rAAVs have been found to transduce substantial numbers of neurons efficiently and to express transgenes in mammalian brains for long periods of time, with minimum inflammatory and immunological responses. In vivo imaging using positron emission tomography is useful for monitoring transgene expression and for assessing the functional effects of gene delivery. Vector systems that regulate transgene expression are necessary to increase safety in clinical applications, and the development of such systems is in progress." @default.
- W2133637743 created "2016-06-24" @default.
- W2133637743 creator A5002986053 @default.
- W2133637743 creator A5038010166 @default.
- W2133637743 creator A5050131030 @default.
- W2133637743 creator A5087113538 @default.
- W2133637743 date "2005-05-01" @default.
- W2133637743 modified "2023-10-11" @default.
- W2133637743 title "Gene therapy for Parkinson’s disease using recombinant adeno-associated viral vectors" @default.
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- W2133637743 doi "https://doi.org/10.1517/14712598.5.5.663" @default.
- W2133637743 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15934841" @default.
- W2133637743 hasPublicationYear "2005" @default.
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