Matches in SemOpenAlex for { <https://semopenalex.org/work/W2133647577> ?p ?o ?g. }
- W2133647577 endingPage "2826" @default.
- W2133647577 startingPage "2818" @default.
- W2133647577 abstract "Metaplasticity describes the stabilization of synaptic strength such that strong synapses are likely to remain strong while weak synapses are likely to remain weak. A potential mechanism for metaplasticity is a correlated change in both N-methyl-D-aspartate (NMDA) receptor-mediated postsynaptic conductance and synaptic strength. Synchronous activation of CA3-CA3 synapses during spontaneous bursts of population activity caused long-term potentiation (LTP) of recurrent CA3-CA3 glutamatergic synapses under control conditions and depotentiation when NMDA receptors were partially blocked by competitive antagonists. LTP was associated with a significant increase in membrane-bound NMDA receptors, whereas depotentiation was associated with a significant decrease in membrane-bound NMDA receptors. During burst activity, further depotentiation could be induced by sequential reductions in antagonist concentration, consistent with a depotentiation-associated reduction in membrane-bound NMDA receptors. The decrease in number of membrane-bound NMDA receptors associated with depotentiation reduced the probability of subsequent potentiation of weakened synapses in the face of ongoing synchronous network activity. This molecular mechanism stabilizes synaptic strength, which in turn stabilizes the state of the CA3 neuronal network, reflected in the frequency of spontaneous population bursts." @default.
- W2133647577 created "2016-06-24" @default.
- W2133647577 creator A5037851639 @default.
- W2133647577 creator A5040224733 @default.
- W2133647577 creator A5076858916 @default.
- W2133647577 creator A5081270367 @default.
- W2133647577 creator A5086063529 @default.
- W2133647577 creator A5086445291 @default.
- W2133647577 creator A5087874207 @default.
- W2133647577 date "2007-11-01" @default.
- W2133647577 modified "2023-10-16" @default.
- W2133647577 title "NMDA Receptor Trafficking at Recurrent Synapses Stabilizes the State of the CA3 Network" @default.
- W2133647577 cites W133569429 @default.
- W2133647577 cites W1498226540 @default.
- W2133647577 cites W1558650798 @default.
- W2133647577 cites W1577190501 @default.
- W2133647577 cites W1577210796 @default.
- W2133647577 cites W1591829725 @default.
- W2133647577 cites W1735445987 @default.
- W2133647577 cites W1957331510 @default.
- W2133647577 cites W1966517040 @default.
- W2133647577 cites W1973213222 @default.
- W2133647577 cites W1976175452 @default.
- W2133647577 cites W1979317467 @default.
- W2133647577 cites W1980527519 @default.
- W2133647577 cites W1988518240 @default.
- W2133647577 cites W1996268509 @default.
- W2133647577 cites W2003436719 @default.
- W2133647577 cites W2005148909 @default.
- W2133647577 cites W2005609503 @default.
- W2133647577 cites W2006423612 @default.
- W2133647577 cites W2011735714 @default.
- W2133647577 cites W2020272049 @default.
- W2133647577 cites W2020939800 @default.
- W2133647577 cites W2023584631 @default.
- W2133647577 cites W2037221789 @default.
- W2133647577 cites W2041800086 @default.
- W2133647577 cites W2050066016 @default.
- W2133647577 cites W2059602156 @default.
- W2133647577 cites W2062431479 @default.
- W2133647577 cites W2072282121 @default.
- W2133647577 cites W2076969814 @default.
- W2133647577 cites W2078797296 @default.
- W2133647577 cites W2087656275 @default.
- W2133647577 cites W2095774626 @default.
- W2133647577 cites W2102137096 @default.
- W2133647577 cites W2123067258 @default.
- W2133647577 cites W2125993131 @default.
- W2133647577 cites W2127087627 @default.
- W2133647577 cites W2129952903 @default.
- W2133647577 cites W2134680445 @default.
- W2133647577 cites W2141911467 @default.
- W2133647577 cites W2146459042 @default.
- W2133647577 cites W2155585976 @default.
- W2133647577 cites W2157365188 @default.
- W2133647577 cites W2162593608 @default.
- W2133647577 cites W2321193734 @default.
- W2133647577 cites W4232263592 @default.
- W2133647577 cites W4241962141 @default.
- W2133647577 cites W2007586575 @default.
- W2133647577 doi "https://doi.org/10.1152/jn.00346.2007" @default.
- W2133647577 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17728388" @default.
- W2133647577 hasPublicationYear "2007" @default.
- W2133647577 type Work @default.
- W2133647577 sameAs 2133647577 @default.
- W2133647577 citedByCount "12" @default.
- W2133647577 countsByYear W21336475772012 @default.
- W2133647577 countsByYear W21336475772013 @default.
- W2133647577 countsByYear W21336475772014 @default.
- W2133647577 countsByYear W21336475772015 @default.
- W2133647577 countsByYear W21336475772018 @default.
- W2133647577 countsByYear W21336475772023 @default.
- W2133647577 crossrefType "journal-article" @default.
- W2133647577 hasAuthorship W2133647577A5037851639 @default.
- W2133647577 hasAuthorship W2133647577A5040224733 @default.
- W2133647577 hasAuthorship W2133647577A5076858916 @default.
- W2133647577 hasAuthorship W2133647577A5081270367 @default.
- W2133647577 hasAuthorship W2133647577A5086063529 @default.
- W2133647577 hasAuthorship W2133647577A5086445291 @default.
- W2133647577 hasAuthorship W2133647577A5087874207 @default.
- W2133647577 hasBestOaLocation W21336475772 @default.
- W2133647577 hasConcept C112592302 @default.
- W2133647577 hasConcept C160268369 @default.
- W2133647577 hasConcept C169760540 @default.
- W2133647577 hasConcept C170493617 @default.
- W2133647577 hasConcept C185592680 @default.
- W2133647577 hasConcept C194973443 @default.
- W2133647577 hasConcept C25274449 @default.
- W2133647577 hasConcept C2780648746 @default.
- W2133647577 hasConcept C2908647359 @default.
- W2133647577 hasConcept C55493867 @default.
- W2133647577 hasConcept C61174792 @default.
- W2133647577 hasConcept C67018056 @default.
- W2133647577 hasConcept C71924100 @default.
- W2133647577 hasConcept C73009533 @default.
- W2133647577 hasConcept C86803240 @default.
- W2133647577 hasConcept C99454951 @default.
- W2133647577 hasConceptScore W2133647577C112592302 @default.