FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2133648811> ?p ?o ?g. }

• W2133648811 endingPage "1937" @default.
• W2133648811 startingPage "1932" @default.
• W2133648811 abstract "Thrombotic thrombocytopenic purpura (TTP) is a life-threatening disease that occurs mainly in young adults. Acquired cases are usually a result of antibodies directed against ADAMTS13 (a disintegrin-like and metalloprotease [reprolysin type] with thrombospondin type 1 motif 13), a protease that cleaves the von Willebrand factor multimers. Prognosis has been improved by plasma therapy, but some acute severe forms are refractory to this treatment and achieving a sustained remission is still a challenge in chronic relapsing forms. We therefore conducted a multicentric open-label prospective trial to test the efficacy of rituximab, an anti-B-cell monoclonal antibody, as a curative and prophylactic treatment in patients with TTP as a result of anti-ADAMTS13 antibodies. Six patients were included during an acute refractory TTP episode. Five patients with severe relapsing TTP and persistent anti-ADAMTS13 antibodies were prophylactically treated during remission. All patients received 4 weekly infusions of rituximab. The target of treatment was to restore a significant ADAMTS13 plasma activity (> 10%). Treatment with rituximab led to clinical remission in all cases of acute refractory TTP. In all patients, anti-ADAMTS13 antibodies disappeared, and a significant (18%-75%) plasma ADAMTS13 activity was detected following treatment. Tolerance of rituximab was good. Rituximab is a promising first-line immunosuppressive treatment in patients with acute refractory and severe relapsing TTP related to anti-ADAMTS13 antibodies." @default.
• W2133648811 created "2016-06-24" @default.
• W2133648811 creator A5010505148 @default.
• W2133648811 creator A5010758794 @default.
• W2133648811 creator A5012365297 @default.
• W2133648811 creator A5012717738 @default.
• W2133648811 creator A5014942120 @default.
• W2133648811 creator A5023556434 @default.
• W2133648811 creator A5037817902 @default.
• W2133648811 creator A5040988386 @default.
• W2133648811 creator A5059268248 @default.
• W2133648811 creator A5059529448 @default.
• W2133648811 creator A5062415416 @default.
• W2133648811 creator A5073828452 @default.
• W2133648811 creator A5074564085 @default.
• W2133648811 creator A5080908134 @default.
• W2133648811 creator A5088509972 @default.
• W2133648811 creator A5091587971 @default.
• W2133648811 date "2005-09-15" @default.
• W2133648811 modified "2023-10-12" @default.
• W2133648811 title "Efficiency of curative and prophylactic treatment with rituximab in ADAMTS13-deficient thrombotic thrombocytopenic purpura: a study of 11 cases" @default.
• W2133648811 cites W1965695621 @default.
• W2133648811 cites W1969467075 @default.
• W2133648811 cites W1969715141 @default.
• W2133648811 cites W1977622626 @default.
• W2133648811 cites W1978858820 @default.
• W2133648811 cites W1980762761 @default.
• W2133648811 cites W1982852792 @default.
• W2133648811 cites W1995127039 @default.
• W2133648811 cites W2000179783 @default.
• W2133648811 cites W2015445458 @default.
• W2133648811 cites W2017709470 @default.
• W2133648811 cites W2020077683 @default.
• W2133648811 cites W2022736080 @default.
• W2133648811 cites W2025214976 @default.
• W2133648811 cites W2028492855 @default.
• W2133648811 cites W2034553419 @default.
• W2133648811 cites W2046059252 @default.
• W2133648811 cites W2049473604 @default.
• W2133648811 cites W2052449117 @default.
• W2133648811 cites W2071998860 @default.
• W2133648811 cites W2075485887 @default.
• W2133648811 cites W2077409993 @default.
• W2133648811 cites W2083670536 @default.
• W2133648811 cites W2121848782 @default.
• W2133648811 cites W2145427481 @default.
• W2133648811 cites W2147498528 @default.
• W2133648811 cites W2155933413 @default.
• W2133648811 cites W2160606302 @default.
• W2133648811 cites W2164819810 @default.
• W2133648811 cites W2165163748 @default.
• W2133648811 cites W2166358470 @default.
• W2133648811 cites W2170134021 @default.
• W2133648811 cites W2315229770 @default.
• W2133648811 doi "https://doi.org/10.1182/blood-2005-03-0848" @default.
• W2133648811 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15933059" @default.
• W2133648811 hasPublicationYear "2005" @default.
• W2133648811 type Work @default.
• W2133648811 sameAs 2133648811 @default.
• W2133648811 citedByCount "252" @default.
• W2133648811 countsByYear W21336488112012 @default.
• W2133648811 countsByYear W21336488112013 @default.
• W2133648811 countsByYear W21336488112014 @default.
• W2133648811 countsByYear W21336488112015 @default.
• W2133648811 countsByYear W21336488112016 @default.
• W2133648811 countsByYear W21336488112017 @default.
• W2133648811 countsByYear W21336488112018 @default.
• W2133648811 countsByYear W21336488112019 @default.
• W2133648811 countsByYear W21336488112020 @default.
• W2133648811 countsByYear W21336488112021 @default.
• W2133648811 countsByYear W21336488112022 @default.
• W2133648811 countsByYear W21336488112023 @default.
• W2133648811 crossrefType "journal-article" @default.
• W2133648811 hasAuthorship W2133648811A5010505148 @default.
• W2133648811 hasAuthorship W2133648811A5010758794 @default.
• W2133648811 hasAuthorship W2133648811A5012365297 @default.
• W2133648811 hasAuthorship W2133648811A5012717738 @default.
• W2133648811 hasAuthorship W2133648811A5014942120 @default.
• W2133648811 hasAuthorship W2133648811A5023556434 @default.
• W2133648811 hasAuthorship W2133648811A5037817902 @default.
• W2133648811 hasAuthorship W2133648811A5040988386 @default.
• W2133648811 hasAuthorship W2133648811A5059268248 @default.
• W2133648811 hasAuthorship W2133648811A5059529448 @default.
• W2133648811 hasAuthorship W2133648811A5062415416 @default.
• W2133648811 hasAuthorship W2133648811A5073828452 @default.
• W2133648811 hasAuthorship W2133648811A5074564085 @default.
• W2133648811 hasAuthorship W2133648811A5080908134 @default.
• W2133648811 hasAuthorship W2133648811A5088509972 @default.
• W2133648811 hasAuthorship W2133648811A5091587971 @default.
• W2133648811 hasBestOaLocation W21336488111 @default.
• W2133648811 hasConcept C126322002 @default.
• W2133648811 hasConcept C159654299 @default.
• W2133648811 hasConcept C187212893 @default.
• W2133648811 hasConcept C203014093 @default.
• W2133648811 hasConcept C2778585876 @default.
• W2133648811 hasConcept C2780653079 @default.
• W2133648811 hasConcept C2780921031 @default.
• W2133648811 hasConcept C71924100 @default.

• next