FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2133662632> ?p ?o ?g. }

• W2133662632 endingPage "53" @default.
• W2133662632 startingPage "44" @default.
• W2133662632 abstract "L-3-hydroxyacyl-coenzyme A dehydrogenase type II (HADH) was described as an endoplasmic reticulum amyloid beta-peptide-binding protein (ERAB), which enhances Abeta toxicity, and accumulates in neurons in Alzheimer's disease (AD). Hence, HADH/ERAB was suggested to mediate the amyloid-induced neurodegeneration. We estimated the in vivo interactions of HADH and Abeta in an immunocytochemical study of ten Alzheimer's disease and seven normal brains using five monoclonal HADH-specific antibodies. We found no HADH in amyloid plaques or vascular amyloid. The neuronal expression of HADH was not correlated with the severity of amyloid load in neuropil. HADH was expressed in vascular smooth muscle cells in young and old controls and in amyloid-free blood vessels in AD cases, but little or no HADH was in smooth muscle cells in arteries with amyloid deposits. The putative intracellular interaction between HADH and Abeta in amyloid-producing cells was further studied in vascular smooth muscle cells isolated from brain blood vessels with amyloid-beta angiopathy - the cells that were shown previously to accumulate Abeta intracellularly ['Research advances in Alzheimer's disease and related disorders' (1995) 747; Brain Res. 676 (1995) 225; Neurosci. Lett. 183 (1995) 120]. HADH had a mitochondrial localization and did not co-localize with an endoplasmic reticulum marker. Cells that accumulated Abeta were those with low expression of HADH and the proteins did not co-localize. Explanation of the association between low levels of HADH and deposition of Abeta by brain smooth muscle cells requires further studies." @default.
• W2133662632 created "2016-06-24" @default.
• W2133662632 creator A5009533777 @default.
• W2133662632 creator A5060049713 @default.
• W2133662632 creator A5075326447 @default.
• W2133662632 creator A5075518800 @default.
• W2133662632 date "2001-07-01" @default.
• W2133662632 modified "2023-10-18" @default.
• W2133662632 title "Deposition of Alzheimer’s vascular amyloid-β is associated with decreased expression of brain l-3-hydroxyacyl-coenzyme A dehydrogenase (ERAB)" @default.
• W2133662632 cites W1967684462 @default.
• W2133662632 cites W1969547229 @default.
• W2133662632 cites W1970802745 @default.
• W2133662632 cites W1972094490 @default.
• W2133662632 cites W1972992370 @default.
• W2133662632 cites W1975775468 @default.
• W2133662632 cites W1976721815 @default.
• W2133662632 cites W1980847537 @default.
• W2133662632 cites W1983996266 @default.
• W2133662632 cites W1984996311 @default.
• W2133662632 cites W1985325561 @default.
• W2133662632 cites W1988861131 @default.
• W2133662632 cites W1992358503 @default.
• W2133662632 cites W2011424449 @default.
• W2133662632 cites W2018086392 @default.
• W2133662632 cites W2020945366 @default.
• W2133662632 cites W2024304291 @default.
• W2133662632 cites W2075527514 @default.
• W2133662632 cites W2077017147 @default.
• W2133662632 cites W2079438371 @default.
• W2133662632 cites W2084559483 @default.
• W2133662632 cites W2088469374 @default.
• W2133662632 cites W2091579589 @default.
• W2133662632 cites W2092760875 @default.
• W2133662632 cites W2117037463 @default.
• W2133662632 cites W2138765938 @default.
• W2133662632 cites W2166403860 @default.
• W2133662632 doi "https://doi.org/10.1016/s0006-8993(01)02497-0" @default.
• W2133662632 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11430884" @default.
• W2133662632 hasPublicationYear "2001" @default.
• W2133662632 type Work @default.
• W2133662632 sameAs 2133662632 @default.
• W2133662632 citedByCount "33" @default.
• W2133662632 countsByYear W21336626322012 @default.
• W2133662632 countsByYear W21336626322013 @default.
• W2133662632 countsByYear W21336626322015 @default.
• W2133662632 countsByYear W21336626322016 @default.
• W2133662632 countsByYear W21336626322018 @default.
• W2133662632 countsByYear W21336626322019 @default.
• W2133662632 countsByYear W21336626322020 @default.
• W2133662632 countsByYear W21336626322022 @default.
• W2133662632 countsByYear W21336626322023 @default.
• W2133662632 crossrefType "journal-article" @default.
• W2133662632 hasAuthorship W2133662632A5009533777 @default.
• W2133662632 hasAuthorship W2133662632A5060049713 @default.
• W2133662632 hasAuthorship W2133662632A5075326447 @default.
• W2133662632 hasAuthorship W2133662632A5075518800 @default.
• W2133662632 hasConcept C126322002 @default.
• W2133662632 hasConcept C134018914 @default.
• W2133662632 hasConcept C142724271 @default.
• W2133662632 hasConcept C158617107 @default.
• W2133662632 hasConcept C2777633098 @default.
• W2133662632 hasConcept C2777831001 @default.
• W2133662632 hasConcept C2779134260 @default.
• W2133662632 hasConcept C2779395532 @default.
• W2133662632 hasConcept C2779703115 @default.
• W2133662632 hasConcept C2992686903 @default.
• W2133662632 hasConcept C31705614 @default.
• W2133662632 hasConcept C502032728 @default.
• W2133662632 hasConcept C529278444 @default.
• W2133662632 hasConcept C55493867 @default.
• W2133662632 hasConcept C555293320 @default.
• W2133662632 hasConcept C59822182 @default.
• W2133662632 hasConcept C71924100 @default.
• W2133662632 hasConcept C86803240 @default.
• W2133662632 hasConceptScore W2133662632C126322002 @default.
• W2133662632 hasConceptScore W2133662632C134018914 @default.
• W2133662632 hasConceptScore W2133662632C142724271 @default.
• W2133662632 hasConceptScore W2133662632C158617107 @default.
• W2133662632 hasConceptScore W2133662632C2777633098 @default.
• W2133662632 hasConceptScore W2133662632C2777831001 @default.
• W2133662632 hasConceptScore W2133662632C2779134260 @default.
• W2133662632 hasConceptScore W2133662632C2779395532 @default.
• W2133662632 hasConceptScore W2133662632C2779703115 @default.
• W2133662632 hasConceptScore W2133662632C2992686903 @default.
• W2133662632 hasConceptScore W2133662632C31705614 @default.
• W2133662632 hasConceptScore W2133662632C502032728 @default.
• W2133662632 hasConceptScore W2133662632C529278444 @default.
• W2133662632 hasConceptScore W2133662632C55493867 @default.
• W2133662632 hasConceptScore W2133662632C555293320 @default.
• W2133662632 hasConceptScore W2133662632C59822182 @default.
• W2133662632 hasConceptScore W2133662632C71924100 @default.
• W2133662632 hasConceptScore W2133662632C86803240 @default.
• W2133662632 hasIssue "1-2" @default.
• W2133662632 hasLocation W21336626321 @default.
• W2133662632 hasLocation W21336626322 @default.
• W2133662632 hasOpenAccess W2133662632 @default.
• W2133662632 hasPrimaryLocation W21336626321 @default.
• W2133662632 hasRelatedWork W2044388435 @default.

• next