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• W2133668831 endingPage "875" @default.
• W2133668831 startingPage "865" @default.
• W2133668831 abstract "The discovery of chromosomal rearrangements involving the anaplastic lymphoma kinase (ALK) gene in non-small cell lung cancer (NSCLC) has stimulated renewed interest in oncogenic fusions as potential therapeutic targets. Recently, genetic alterations in ROS1 and RET were identified in patients with NSCLC. Like ALK, genetic alterations in ROS1 and RET involve chromosomal rearrangements that result in the formation of chimeric fusion kinases capable of oncogenic transformation. Notably, ROS1 and RET rearrangements are rarely found with other genetic alterations, such as EGFR, KRAS, or ALK. This finding suggests that both ROS1 and RET are independent oncogenic drivers that may be viable therapeutic targets. In initial screening studies, ROS1 and RET rearrangements were identified at similar frequencies (approximately 1%-2%), using a variety of genotyping techniques. Importantly, patients with either ROS1 or RET rearrangements appear to have unique clinical and pathologic features that may facilitate identification and enrichment strategies. These features may in turn expedite enrollment in clinical trials evaluating genotype-directed therapies in these rare patient populations. In this review, we summarize the molecular biology, clinical features, detection, and targeting of ROS1 and RET rearrangements in NSCLC." @default.
• W2133668831 created "2016-06-24" @default.
• W2133668831 creator A5080311196 @default.
• W2133668831 creator A5081227348 @default.
• W2133668831 date "2013-06-28" @default.
• W2133668831 modified "2023-10-16" @default.
• W2133668831 title "Novel Targets in Non-Small Cell Lung Cancer: <i>ROS1</i> and <i>RET</i> Fusions" @default.
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• W2133668831 doi "https://doi.org/10.1634/theoncologist.2013-0095" @default.
• W2133668831 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3720641" @default.
• W2133668831 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23814043" @default.
• W2133668831 hasPublicationYear "2013" @default.

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