Matches in SemOpenAlex for { <https://semopenalex.org/work/W2133669849> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2133669849 endingPage "458" @default.
- W2133669849 startingPage "445" @default.
- W2133669849 abstract "1. Nodose ganglion neurones (NGNs) become less excitable following section of the vagus nerve. To determine the role of sodium currents (I(Na)) in these changes, standard patch-clamp recording techniques were used to measure I(Na) in rat NGNs maintained in vivo for 5-6 days following vagotomy, and then in vitro for 2-9 h. 2. Total I(Na) and I(Na) density in vagotomized NGNs were similar to control values. However, steady-state I(Na) inactivation in vagotomized NGNs was shifted -9 mV relative to control values (V(1/2), -74 +/- 2 vs. -65 +/- 2 mV, P < 0.01) and I(Na) activation was shifted by -7 mV (V(1/2), -21 +/- 2 vs. -14 +/- 2 mV, P < 0.006). I(Na) recovery from inactivation was also slower in vagotomized NGNs (fast time constant, 2.8 +/- 0.4 vs. 1.6 +/- 0.3 ms, P < 0.02). 3. The fraction of I(Na) resistant to 1 microM tetrodotoxin (TTX-R) was halved in vagotomized NGNs (21 +/- 8 vs. 56 +/- 8 % of total I(Na), P < 0.05). This change from TTX-R I(Na) to TTX-sensitive (TTX-S) I(Na) may explain altered I(Na) activation, inactivation and repriming in vagotomized NGNs. 4. The contribution of alterations in I(Na) to NGN firing patterns was assessed by measuring I(Na) evoked by a series of action potential (AP) waveforms. In general, control NGNs produced large, repetitive TTX-R I(Na) while vagotomized NGNs produced smaller TTX-S I(Na) that rapidly inactivated during AP discharge. We conclude that TTX-R I(Na) is important for sustained AP discharge in NGNs, and that its diminution underlies the decreased AP discharge of vagotomized NGNs." @default.
- W2133669849 created "2016-06-24" @default.
- W2133669849 creator A5008690029 @default.
- W2133669849 creator A5028857720 @default.
- W2133669849 date "2001-10-01" @default.
- W2133669849 modified "2023-09-26" @default.
- W2133669849 title "Sodium currents in vagotomized primary afferent neurones of the rat" @default.
- W2133669849 cites W1623378741 @default.
- W2133669849 cites W163542638 @default.
- W2133669849 cites W1801616206 @default.
- W2133669849 cites W1816134939 @default.
- W2133669849 cites W1844967107 @default.
- W2133669849 cites W1951749181 @default.
- W2133669849 cites W1963637213 @default.
- W2133669849 cites W1996754501 @default.
- W2133669849 cites W1997511216 @default.
- W2133669849 cites W1999707600 @default.
- W2133669849 cites W2000702493 @default.
- W2133669849 cites W2009667219 @default.
- W2133669849 cites W2015426350 @default.
- W2133669849 cites W2018809272 @default.
- W2133669849 cites W2022050392 @default.
- W2133669849 cites W2028752842 @default.
- W2133669849 cites W2030322776 @default.
- W2133669849 cites W2032809866 @default.
- W2133669849 cites W2034090077 @default.
- W2133669849 cites W2037361891 @default.
- W2133669849 cites W2065857917 @default.
- W2133669849 cites W2071595010 @default.
- W2133669849 cites W2091746433 @default.
- W2133669849 cites W2105493663 @default.
- W2133669849 cites W2117266710 @default.
- W2133669849 cites W2134321467 @default.
- W2133669849 cites W2209993503 @default.
- W2133669849 cites W2238188566 @default.
- W2133669849 cites W2252378079 @default.
- W2133669849 cites W2331570632 @default.
- W2133669849 doi "https://doi.org/10.1111/j.1469-7793.2001.0445c.xd" @default.
- W2133669849 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2278870" @default.
- W2133669849 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11600680" @default.
- W2133669849 hasPublicationYear "2001" @default.
- W2133669849 type Work @default.
- W2133669849 sameAs 2133669849 @default.
- W2133669849 citedByCount "21" @default.
- W2133669849 countsByYear W21336698492013 @default.
- W2133669849 countsByYear W21336698492014 @default.
- W2133669849 countsByYear W21336698492017 @default.
- W2133669849 countsByYear W21336698492021 @default.
- W2133669849 countsByYear W21336698492022 @default.
- W2133669849 crossrefType "journal-article" @default.
- W2133669849 hasAuthorship W2133669849A5008690029 @default.
- W2133669849 hasAuthorship W2133669849A5028857720 @default.
- W2133669849 hasBestOaLocation W21336698492 @default.
- W2133669849 hasConcept C126322002 @default.
- W2133669849 hasConcept C185592680 @default.
- W2133669849 hasConcept C2776741303 @default.
- W2133669849 hasConcept C2778720886 @default.
- W2133669849 hasConcept C71924100 @default.
- W2133669849 hasConceptScore W2133669849C126322002 @default.
- W2133669849 hasConceptScore W2133669849C185592680 @default.
- W2133669849 hasConceptScore W2133669849C2776741303 @default.
- W2133669849 hasConceptScore W2133669849C2778720886 @default.
- W2133669849 hasConceptScore W2133669849C71924100 @default.
- W2133669849 hasIssue "2" @default.
- W2133669849 hasLocation W21336698491 @default.
- W2133669849 hasLocation W21336698492 @default.
- W2133669849 hasLocation W21336698493 @default.
- W2133669849 hasOpenAccess W2133669849 @default.
- W2133669849 hasPrimaryLocation W21336698491 @default.
- W2133669849 hasRelatedWork W1978346285 @default.
- W2133669849 hasRelatedWork W2079088549 @default.
- W2133669849 hasRelatedWork W2107380129 @default.
- W2133669849 hasRelatedWork W2108722175 @default.
- W2133669849 hasRelatedWork W2133669849 @default.
- W2133669849 hasRelatedWork W2332206887 @default.
- W2133669849 hasRelatedWork W236364969 @default.
- W2133669849 hasRelatedWork W2899084033 @default.
- W2133669849 hasRelatedWork W2948807893 @default.
- W2133669849 hasRelatedWork W4299545220 @default.
- W2133669849 hasVolume "536" @default.
- W2133669849 isParatext "false" @default.
- W2133669849 isRetracted "false" @default.
- W2133669849 magId "2133669849" @default.
- W2133669849 workType "article" @default.