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- W2133670133 abstract "Intact red blood cells (RBCs) undergo a sudden change from blocking to passing through 1.3 /spl mu/m-micropipettes at a transition temperature (T/sub c/) of 36.4/spl deg/C and -2.3 kPa aspiration pressure. This was attributed to a change of the physical state of hemoglobin. Since Ca/sup 2+/-ions induce conformational changes of proteins, we studied how elevated intracellular Ca/sup 2+/ would effect the RBC passage through micropipettes and T/sub c/. Transitions occurred in A23187-treated RBCs at 1 mM extraneous Ca/sup 2+/ as well. Surprisingly, T/sub c/ remained at 36.4/spl deg/C. However, higher aspiration forces (pipette diameter: 1.7 /spl mu/m) were needed for passages. To look at hemoglobin only, low shear viscosity measurements of hemoglobin solutions at 50 g/dl were carried out as a function of temperature and different Ca concentrations (1.8, 9 and 18 mM). When raising the temperature, a sudden viscosity drop occurred between 35/spl deg/C-38/spl deg/C. However, the absolute difference of viscosities at 35/spl deg/C compared to 38/spl deg/C was lower at 9 mM and had almost disappeared at 18 mM. Furthermore, higher Ca/sup 2+/-levels led to lower viscosities at all temperatures investigated. This may be due to the binding of calcium to hemoglobin molecules, which in turn may have weakened intermolecular bonds leading to a fluidization of hemoglobin solutions at high calcium levels." @default.
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- W2133670133 date "2003-01-20" @default.
- W2133670133 modified "2023-09-27" @default.
- W2133670133 title "Effects of Ca/sup 2+/ on the temperature transition of hemoglobin properties in human red blood cells" @default.
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- W2133670133 doi "https://doi.org/10.1109/iembs.1999.802111" @default.
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