FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2133670757> ?p ?o ?g. }

• W2133670757 endingPage "474" @default.
• W2133670757 startingPage "465" @default.
• W2133670757 abstract "Dioxin is a ubiquitous environmental pollutant that induces toxicity when bound to the aryl hydrocarbon receptor (AhR). Significant differences in susceptibility of mouse strains to dioxin toxicity are largely accounted for by the dissociation constant of binding to dioxins of AhR subtypes encoded by different alleles. We showed that cyclooxygenase-2 (COX-2) and microsomal prostaglandin E synthase-1 (mPGES-1), components of a prostanoid synthesis pathway, play essential roles in the onset of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induced hydronephrosis of neonatal mice. Although C57BL/6J and BALB/cA mice harbor AhR receptors highly responsive to TCDD, they were found by chance to differ significantly in the incidence of TCDD-induced hydronephrosis. Therefore, the goal of the present study was to determine the molecular basis of this difference in susceptibility to TCDD toxicity. For this purpose, we administered C57BL/6J and BALB/cA dams' TCDD at an oral dose of 15 or 80 μg/kg on postnatal day (PND) 1 to expose pups to TCDD via lactation, and the pups' kidneys were collected on PND 7. The incidence of hydronephrosis in C57BL/6J pups (64%) was greater than in BALB/cA pups (0%, p < 0.05), despite similarly increased levels of COX-2 mRNA. The incidence of hydronephrosis in these mouse strains paralleled the levels of renal mPGES-1 mRNA and early growth response 1 (Egr-1) that modulates mPGES-1 gene expression, as well as PGE2 concentrations in urine. Although these mouse strains possess AhR alleles tightly bound to TCDD, their difference in incidence and severity of hydronephrosis can be explained, in part, by differences in the expression of mPGES-1 and Egr-1." @default.
• W2133670757 created "2016-06-24" @default.
• W2133670757 creator A5007577173 @default.
• W2133670757 creator A5039337903 @default.
• W2133670757 creator A5048119729 @default.
• W2133670757 creator A5052305629 @default.
• W2133670757 creator A5064910035 @default.
• W2133670757 date "2014-10-01" @default.
• W2133670757 modified "2023-10-10" @default.
• W2133670757 title "A Mouse Strain Less Responsive to Dioxin-Induced Prostaglandin E2 Synthesis Is Resistant to the Onset of Neonatal Hydronephrosis" @default.
• W2133670757 cites W1537989154 @default.
• W2133670757 cites W1552761055 @default.
• W2133670757 cites W156631889 @default.
• W2133670757 cites W1969091878 @default.
• W2133670757 cites W1970139354 @default.
• W2133670757 cites W1980214543 @default.
• W2133670757 cites W1981541691 @default.
• W2133670757 cites W1984370108 @default.
• W2133670757 cites W1992282800 @default.
• W2133670757 cites W1993471526 @default.
• W2133670757 cites W1995551499 @default.
• W2133670757 cites W1998573431 @default.
• W2133670757 cites W1999989358 @default.
• W2133670757 cites W2000925287 @default.
• W2133670757 cites W2001129603 @default.
• W2133670757 cites W2005861385 @default.
• W2133670757 cites W2006334693 @default.
• W2133670757 cites W2008143869 @default.
• W2133670757 cites W2011582760 @default.
• W2133670757 cites W2012175241 @default.
• W2133670757 cites W2023906945 @default.
• W2133670757 cites W2024875158 @default.
• W2133670757 cites W2028229334 @default.
• W2133670757 cites W2029291103 @default.
• W2133670757 cites W2031205060 @default.
• W2133670757 cites W2037830178 @default.
• W2133670757 cites W2039775584 @default.
• W2133670757 cites W2044544228 @default.
• W2133670757 cites W2046461470 @default.
• W2133670757 cites W2055064469 @default.
• W2133670757 cites W2058097591 @default.
• W2133670757 cites W2059082734 @default.
• W2133670757 cites W2062318487 @default.
• W2133670757 cites W2069306306 @default.
• W2133670757 cites W2073563548 @default.
• W2133670757 cites W2081660694 @default.
• W2133670757 cites W2087332917 @default.
• W2133670757 cites W2089767083 @default.
• W2133670757 cites W2090939833 @default.
• W2133670757 cites W2093853598 @default.
• W2133670757 cites W2095041417 @default.
• W2133670757 cites W2098136511 @default.
• W2133670757 cites W2104118305 @default.
• W2133670757 cites W2105024660 @default.
• W2133670757 cites W2110179924 @default.
• W2133670757 cites W2113750680 @default.
• W2133670757 cites W2115277334 @default.
• W2133670757 cites W2118744236 @default.
• W2133670757 cites W2119409275 @default.
• W2133670757 cites W2123085104 @default.
• W2133670757 cites W2138913971 @default.
• W2133670757 cites W2155310231 @default.
• W2133670757 cites W2160811937 @default.
• W2133670757 cites W2161892241 @default.
• W2133670757 cites W2167029659 @default.
• W2133670757 cites W2170843321 @default.
• W2133670757 doi "https://doi.org/10.1093/toxsci/kfu142" @default.
• W2133670757 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4833024" @default.
• W2133670757 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25015655" @default.
• W2133670757 hasPublicationYear "2014" @default.
• W2133670757 type Work @default.
• W2133670757 sameAs 2133670757 @default.
• W2133670757 citedByCount "8" @default.
• W2133670757 countsByYear W21336707572016 @default.
• W2133670757 countsByYear W21336707572017 @default.
• W2133670757 countsByYear W21336707572019 @default.
• W2133670757 countsByYear W21336707572023 @default.
• W2133670757 crossrefType "journal-article" @default.
• W2133670757 hasAuthorship W2133670757A5007577173 @default.
• W2133670757 hasAuthorship W2133670757A5039337903 @default.
• W2133670757 hasAuthorship W2133670757A5048119729 @default.
• W2133670757 hasAuthorship W2133670757A5052305629 @default.
• W2133670757 hasAuthorship W2133670757A5064910035 @default.
• W2133670757 hasBestOaLocation W21336707571 @default.
• W2133670757 hasConcept C104317684 @default.
• W2133670757 hasConcept C126322002 @default.
• W2133670757 hasConcept C134018914 @default.
• W2133670757 hasConcept C170493617 @default.
• W2133670757 hasConcept C185592680 @default.
• W2133670757 hasConcept C2776659692 @default.
• W2133670757 hasConcept C2779234561 @default.
• W2133670757 hasConcept C2780664492 @default.
• W2133670757 hasConcept C2781040948 @default.
• W2133670757 hasConcept C29730261 @default.
• W2133670757 hasConcept C33594762 @default.
• W2133670757 hasConcept C54355233 @default.
• W2133670757 hasConcept C55493867 @default.
• W2133670757 hasConcept C71924100 @default.

• next