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- W2133671451 abstract "We examined changes and dose-response relationships in lipid peroxidation and antioxidative protective systems in lungs of rats continuously exposed to low levels of nitrogen dioxide for 4 months. JCL:Wistar male rats (13 weeks old) were exposed continuously to 0 (control), 0.4, 1.2, and 4 ppm nitrogen dioxide for 1, 2, 4, 8, 12, and 16 weeks. Lipid peroxidation as measured by ethane exhalation in the breath of rats increased to a maximum during the first week, and then returned to near the initial level at the 4th week. Thereafter, it showed a realised tendency toward increase. Lipid peroxidation in lung homogenates, measured by the thiobarbituric acid reaction, showed a similar pattern to that of ethane exhalation, but the appearance of the maximum was later than that of ethane, and the relative peak height was lower. The activities of some antioxidative protective enzymes, glutathione peroxidase (GPx), glutathione reductase (GR), glucose-6-phosphate dehydrogenase (G6PD), 6-phosphogluconate dehydrogenase (6PGD), superoxide dismutase (SOD), and disulfide reductase (DSR) increased from the first week, reached their maximum levels at the 4th week, and then decreased gradually until the 16th week. The order of the increased ratios against the control group at the 4th week was G6PD > 6PGD > GR > SOD > DSR > GPx, and the activities were dose dependent against nitrogen dioxide levels of 0.4 to 4 ppm in each period. Glutathione S-transferase activity decreased from the 1st to the 4th week, but then recovered to the initial level from the 8th to the 16th week. The content of nonprotein sulfhydryls reached maximum levels at the 4th week, and remained elevated until the 16th week. The time course of vitamin E was similar to that of lipid peroxidation as measured by ethane exhalation rather than those of the protective enzymes. These results show that the protective ability against oxidative stress decreases with long-term exposure to nitrogen dioxide and that lipid peroxidation increases inversely with the protective systems." @default.
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- W2133671451 date "1982-10-01" @default.
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- W2133671451 title "Studies on biochemical effects of nitrogen dioxide" @default.
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- W2133671451 doi "https://doi.org/10.1016/0041-008x(82)90056-4" @default.
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