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• W2133671956 endingPage "9979" @default.
• W2133671956 startingPage "9964" @default.
• W2133671956 abstract "Extragenic sequences in genomes, such as microRNA and CRISPR, are vital players in the cell. Repetitive extragenic palindromic sequences (REPs) are a class of extragenic sequences, which form nucleotide stem-loop structures. REPs are found in many bacterial species at a high copy number and are important in regulation of certain bacterial functions, such as Integration Host Factor recruitment and mRNA turnover. Although a new clade of putative transposases (RAYTs or TnpA REP ) is often associated with an increase in these repeats, it is not clear how these proteins might have directed amplification of REPs. We report here the structure to 2.6 Å of TnpA REP from Escherichia coli MG1655 bound to a REP. Sequence analysis showed that TnpA REP is highly related to the IS 200 /IS 605 family, but in contrast to IS 200 /IS 605 transposases, TnpA REP is a monomer, is auto-inhibited and is active only in manganese. These features suggest that, relative to IS 200 /IS 605 transposases, it has evolved a different mechanism for the movement of discrete segments of DNA and has been severely down-regulated, perhaps to prevent REPs from sweeping through genomes." @default.
• W2133671956 created "2016-06-24" @default.
• W2133671956 creator A5000465980 @default.
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• W2133671956 creator A5082862847 @default.
• W2133671956 date "2012-08-09" @default.
• W2133671956 modified "2023-10-14" @default.
• W2133671956 title "The processing of repetitive extragenic palindromes: the structure of a repetitive extragenic palindrome bound to its associated nuclease" @default.
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• W2133671956 doi "https://doi.org/10.1093/nar/gks741" @default.
• W2133671956 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3479197" @default.
• W2133671956 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22885300" @default.
• W2133671956 hasPublicationYear "2012" @default.
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