Matches in SemOpenAlex for { <https://semopenalex.org/work/W2133673030> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2133673030 endingPage "152" @default.
- W2133673030 startingPage "143" @default.
- W2133673030 abstract "Human erythrocyte glutathione disulfide reductase studied at 37˚C in 100 mM potassium phosphate buffer, pH 7.4, is subject to partial inhibition by GSSG at low (NADPH). Saturation by NADPH is hyperbolic at low (GSSG) and becomes increasingly sigmoidal at high (GSSG). NADP+ is a competitive inhibitor with respect to NADPH at 20-1000 µM GSSG and an uncompetitive inhibitor with respect to GSSG at 33-120 µM NADPH. Studied under special conditions (10 µM NADPH and 1000 µM GSSG), NADP+ exhibits a two-fold effect, inhibition being preceded by activation in the 0- 50 µM effector concentration range. The data are consistent with the ping-pong / sequential ordered hybrid model diverging at the level of E.NADPH. A composite sequential ordered mechanism is suggested, involving two conformational states of free enzyme at equilibrium. While one state is selective for NADPH as the first substrate, the second state adds GSSG to initiate the catalytic cycle. The pathway proceeding through E.GSSG has an apparently lower turnover number than that proceeding through E.NADPH." @default.
- W2133673030 created "2016-06-24" @default.
- W2133673030 creator A5059434116 @default.
- W2133673030 creator A5090915797 @default.
- W2133673030 date "1999-02-25" @default.
- W2133673030 modified "2023-09-26" @default.
- W2133673030 title "On The Kinetics of Human Erythrocyte Glutathione Disulfide Reductase: Does The Enzyme Really Play 'Ping-Pong'?" @default.
- W2133673030 cites W1493439063 @default.
- W2133673030 cites W1507082667 @default.
- W2133673030 cites W1543292456 @default.
- W2133673030 cites W1563384847 @default.
- W2133673030 cites W1983763608 @default.
- W2133673030 cites W1999541004 @default.
- W2133673030 cites W2001226001 @default.
- W2133673030 cites W2035550338 @default.
- W2133673030 cites W2049478093 @default.
- W2133673030 cites W2056037296 @default.
- W2133673030 cites W2061664652 @default.
- W2133673030 cites W2084619555 @default.
- W2133673030 cites W2129946929 @default.
- W2133673030 cites W2197332903 @default.
- W2133673030 cites W248833920 @default.
- W2133673030 hasPublicationYear "1999" @default.
- W2133673030 type Work @default.
- W2133673030 sameAs 2133673030 @default.
- W2133673030 citedByCount "2" @default.
- W2133673030 countsByYear W21336730302012 @default.
- W2133673030 crossrefType "journal-article" @default.
- W2133673030 hasAuthorship W2133673030A5059434116 @default.
- W2133673030 hasAuthorship W2133673030A5090915797 @default.
- W2133673030 hasConcept C121332964 @default.
- W2133673030 hasConcept C12554922 @default.
- W2133673030 hasConcept C134651460 @default.
- W2133673030 hasConcept C148898269 @default.
- W2133673030 hasConcept C165069038 @default.
- W2133673030 hasConcept C181199279 @default.
- W2133673030 hasConcept C185592680 @default.
- W2133673030 hasConcept C2778760513 @default.
- W2133673030 hasConcept C2779179908 @default.
- W2133673030 hasConcept C2781289165 @default.
- W2133673030 hasConcept C28718788 @default.
- W2133673030 hasConcept C43617362 @default.
- W2133673030 hasConcept C538909803 @default.
- W2133673030 hasConcept C55493867 @default.
- W2133673030 hasConcept C62520636 @default.
- W2133673030 hasConcept C71240020 @default.
- W2133673030 hasConcept C86803240 @default.
- W2133673030 hasConceptScore W2133673030C121332964 @default.
- W2133673030 hasConceptScore W2133673030C12554922 @default.
- W2133673030 hasConceptScore W2133673030C134651460 @default.
- W2133673030 hasConceptScore W2133673030C148898269 @default.
- W2133673030 hasConceptScore W2133673030C165069038 @default.
- W2133673030 hasConceptScore W2133673030C181199279 @default.
- W2133673030 hasConceptScore W2133673030C185592680 @default.
- W2133673030 hasConceptScore W2133673030C2778760513 @default.
- W2133673030 hasConceptScore W2133673030C2779179908 @default.
- W2133673030 hasConceptScore W2133673030C2781289165 @default.
- W2133673030 hasConceptScore W2133673030C28718788 @default.
- W2133673030 hasConceptScore W2133673030C43617362 @default.
- W2133673030 hasConceptScore W2133673030C538909803 @default.
- W2133673030 hasConceptScore W2133673030C55493867 @default.
- W2133673030 hasConceptScore W2133673030C62520636 @default.
- W2133673030 hasConceptScore W2133673030C71240020 @default.
- W2133673030 hasConceptScore W2133673030C86803240 @default.
- W2133673030 hasIssue "2" @default.
- W2133673030 hasLocation W21336730301 @default.
- W2133673030 hasOpenAccess W2133673030 @default.
- W2133673030 hasPrimaryLocation W21336730301 @default.
- W2133673030 hasRelatedWork W1489620314 @default.
- W2133673030 hasRelatedWork W1555103147 @default.
- W2133673030 hasRelatedWork W1583303443 @default.
- W2133673030 hasRelatedWork W1659616754 @default.
- W2133673030 hasRelatedWork W1966914283 @default.
- W2133673030 hasRelatedWork W1970296799 @default.
- W2133673030 hasRelatedWork W1983297324 @default.
- W2133673030 hasRelatedWork W2016844429 @default.
- W2133673030 hasRelatedWork W2023308531 @default.
- W2133673030 hasRelatedWork W2025144742 @default.
- W2133673030 hasRelatedWork W2026956659 @default.
- W2133673030 hasRelatedWork W2026958553 @default.
- W2133673030 hasRelatedWork W2052852525 @default.
- W2133673030 hasRelatedWork W2072752695 @default.
- W2133673030 hasRelatedWork W2085748031 @default.
- W2133673030 hasRelatedWork W2128171188 @default.
- W2133673030 hasRelatedWork W2168780523 @default.
- W2133673030 hasRelatedWork W2208933368 @default.
- W2133673030 hasRelatedWork W2332727756 @default.
- W2133673030 hasRelatedWork W2412391147 @default.
- W2133673030 hasVolume "23" @default.
- W2133673030 isParatext "false" @default.
- W2133673030 isRetracted "false" @default.
- W2133673030 magId "2133673030" @default.
- W2133673030 workType "article" @default.