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• W2133673294 abstract "ounds inflicted by cats and dogs are reported to account for 1% yearly of all visits to emergency departments (EDs).1 Although dogs cause most animal-infl icted wounds (95%), infections occur more commonly after cat bites (50% incidence) than dog bites (10% to 15% incidence).2 Cats’ teeth cause deep punctures and seed tissues with their oral bacteria. Pasteurella species, the pathogen isolated most commonly from infected animal bites, is recovered from 50% of infected dog bites and 75% of infected cat bites. Other important pathogens include Streptococci, Staphylococcus aureus, Capnocytophaga, and assorted anaerobic bacteria.3 Erythromycin, clarithromycin, and fi rst-generation cephalosporins are ineff ective against Pasteurella species.4,5 Amoxicillin-clavulanate, other β-lactamase inhibitor combinations, and certain secondand third-generation cephalosporins provide good to excellent activity against most animal-bite pathogens.4,5 Published recommendations cite oral amoxicillin-clavulanate as the drug of choice for mild infections caused by animal bites,6 and hospitalization and intravenous (IV) antibiotics for moderate and severe infections.6-8 Th e latter treatment is expensive and inconvenient. For moderate-to-severe wound infections, you could choose the antibiotic ceftriaxone, a third-generation cephalosporin. Although never directly assessed for clinical efficacy in animalwound infections, it is eff ective against common bite pathogens.9 Its serum half-life of 8 hours permits once-daily dosing and eliminates need for hospitalization merely for drug administration.10 Intramuscular (IM) administration of ceftriaxone is technically simple, rapidly done, and nearly painless, and it eliminates the cost and inconvenience of establishing IV access. Ceftriaxone is covered by most drug plans. Th is paper describes our experience with an ED protocol that used ceftriaxone in the initial phase of outpatient management of seriously infected wounds from animal bites." @default.
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• W2133673294 date "2004-04-01" @default.
• W2133673294 modified "2023-10-11" @default.
• W2133673294 title "Short report: Ceftriaxone for cat and dog bites. Simple outpatient treatment." @default.
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