FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2133684685> ?p ?o ?g. }

• W2133684685 endingPage "306" @default.
• W2133684685 startingPage "299" @default.
• W2133684685 abstract "Context: There are few short-term mouse models of chronic obstructive pulmonary disease (COPD) mimicking the human disease. In addition, p38 is recently recognized as a target for the treatment of COPD. However, the precise mechanism how p38 contributes to the pathogenesis of COPD is still unknown. Objective: We attempted to create a new mouse model for COPD by intra-tracheal administration of a mixture of lipopolysaccharide (LPS) and cigarette smoke solution (CSS), and investigated the importance of the p38 mitogen-activated protein kinase (p38) pathway in the pathogenesis of COPD. Methods: Mice were administered LPS + CSS once a day on days 0–4 and 7–11. Thereafter, CSS alone was administered to mice once a day on days 14–18. On day 28, histopathological changes of the lung were evaluated, and bronchoalveolar lavage fluid (BALF) was subjected to western blot array for cytokines. Transgenic (TG) mice expressing a constitutive-active form of MKK6, a p38-specific activator in the lung, were subjected to our experimental protocol of COPD model. Results: LPS + CSS administration induced enlargement of alveolar air spaces and destruction of lung parenchyma. BALF analyses of the LPS + CSS group revealed an increase in expression levels of several cytokines involved in the pathogenesis of human COPD. These results suggest that our experimental protocol can induce COPD in mice. Likewise, histopathological findings of the lung and induction of cytokines in BALF from MKK6 c.a.-TG mice were more marked than those in WT mice. Conclusion: In a new experimental COPD mouse model, p38 accelerates the development of emphysema." @default.
• W2133684685 created "2016-06-24" @default.
• W2133684685 creator A5005005279 @default.
• W2133684685 creator A5007906422 @default.
• W2133684685 creator A5009873892 @default.
• W2133684685 creator A5011030853 @default.
• W2133684685 creator A5018689347 @default.
• W2133684685 creator A5028157604 @default.
• W2133684685 creator A5032860273 @default.
• W2133684685 creator A5034809896 @default.
• W2133684685 creator A5042854652 @default.
• W2133684685 creator A5049346059 @default.
• W2133684685 creator A5061561828 @default.
• W2133684685 creator A5063610442 @default.
• W2133684685 creator A5070724827 @default.
• W2133684685 date "2014-03-05" @default.
• W2133684685 modified "2023-10-16" @default.
• W2133684685 title "p38 Mitogen-activated protein kinase accelerates emphysema in mouse model of chronic obstructive pulmonary disease" @default.
• W2133684685 cites W1488600638 @default.
• W2133684685 cites W1609604630 @default.
• W2133684685 cites W1964124382 @default.
• W2133684685 cites W1966894313 @default.
• W2133684685 cites W1991265445 @default.
• W2133684685 cites W1997774756 @default.
• W2133684685 cites W2004556227 @default.
• W2133684685 cites W2008260766 @default.
• W2133684685 cites W2016327030 @default.
• W2133684685 cites W2020863153 @default.
• W2133684685 cites W2020986645 @default.
• W2133684685 cites W2043822150 @default.
• W2133684685 cites W2044692010 @default.
• W2133684685 cites W2054931962 @default.
• W2133684685 cites W2063099179 @default.
• W2133684685 cites W2075297735 @default.
• W2133684685 cites W2081130105 @default.
• W2133684685 cites W2084327854 @default.
• W2133684685 cites W2089019771 @default.
• W2133684685 cites W2099692602 @default.
• W2133684685 cites W2099969611 @default.
• W2133684685 cites W2104682044 @default.
• W2133684685 cites W2105084982 @default.
• W2133684685 cites W2109412403 @default.
• W2133684685 cites W2130374023 @default.
• W2133684685 cites W2136530831 @default.
• W2133684685 cites W2145021783 @default.
• W2133684685 cites W2151041131 @default.
• W2133684685 cites W2156035167 @default.
• W2133684685 cites W2158549296 @default.
• W2133684685 cites W2159680207 @default.
• W2133684685 cites W2163261242 @default.
• W2133684685 cites W2167187961 @default.
• W2133684685 cites W2740155436 @default.
• W2133684685 doi "https://doi.org/10.3109/10799893.2014.896380" @default.
• W2133684685 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24593255" @default.
• W2133684685 hasPublicationYear "2014" @default.
• W2133684685 type Work @default.
• W2133684685 sameAs 2133684685 @default.
• W2133684685 citedByCount "12" @default.
• W2133684685 countsByYear W21336846852014 @default.
• W2133684685 countsByYear W21336846852015 @default.
• W2133684685 countsByYear W21336846852016 @default.
• W2133684685 countsByYear W21336846852017 @default.
• W2133684685 countsByYear W21336846852020 @default.
• W2133684685 countsByYear W21336846852021 @default.
• W2133684685 countsByYear W21336846852022 @default.
• W2133684685 crossrefType "journal-article" @default.
• W2133684685 hasAuthorship W2133684685A5005005279 @default.
• W2133684685 hasAuthorship W2133684685A5007906422 @default.
• W2133684685 hasAuthorship W2133684685A5009873892 @default.
• W2133684685 hasAuthorship W2133684685A5011030853 @default.
• W2133684685 hasAuthorship W2133684685A5018689347 @default.
• W2133684685 hasAuthorship W2133684685A5028157604 @default.
• W2133684685 hasAuthorship W2133684685A5032860273 @default.
• W2133684685 hasAuthorship W2133684685A5034809896 @default.
• W2133684685 hasAuthorship W2133684685A5042854652 @default.
• W2133684685 hasAuthorship W2133684685A5049346059 @default.
• W2133684685 hasAuthorship W2133684685A5061561828 @default.
• W2133684685 hasAuthorship W2133684685A5063610442 @default.
• W2133684685 hasAuthorship W2133684685A5070724827 @default.
• W2133684685 hasConcept C102230213 @default.
• W2133684685 hasConcept C104317684 @default.
• W2133684685 hasConcept C126322002 @default.
• W2133684685 hasConcept C141035611 @default.
• W2133684685 hasConcept C142724271 @default.
• W2133684685 hasConcept C151730666 @default.
• W2133684685 hasConcept C164027704 @default.
• W2133684685 hasConcept C184235292 @default.
• W2133684685 hasConcept C203014093 @default.
• W2133684685 hasConcept C2776415932 @default.
• W2133684685 hasConcept C2776780178 @default.
• W2133684685 hasConcept C2776914184 @default.
• W2133684685 hasConcept C2777714996 @default.
• W2133684685 hasConcept C2777961210 @default.
• W2133684685 hasConcept C2779343474 @default.
• W2133684685 hasConcept C2780942790 @default.
• W2133684685 hasConcept C51551487 @default.
• W2133684685 hasConcept C55493867 @default.
• W2133684685 hasConcept C71924100 @default.

• next