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• W2133685976 abstract "Estudiar la prevalencia de inmunización frente al virus de la hepatitis A (VHA) en personas infectadas por el virus de la hepatitis C (VHC), con el fin de indicar la vacunación. Estudio descriptivo transversal. Centro urbano (12.000 habitantes). Pacientes positivos para el VHC mayores de 14 años. Variables: presencia de hepatopatía crónica, serologías de hepatitis B y A e inmunodeficiencia humana (VIH), vacunación de hepatitis B. La muestra de pacientes positivos para el VHC se componía de 134 personas, el 70,9% varones y el 29,1% mujeres. Edad media: 41,75 (DE, 16,55) años. El 93,3% presentaba hepatopatía crónica, el 56,7% era usuario de drogas por vía parenteral (UDVP), el 56% era HBcAc positivo y el 32,8% VIH positivo. La serología del VHA se realizó a 75 pacientes (56%), y fue positiva en el 86,7%. La edad media en los pacientes VHA+ era de 50,4 (DE, 17,8) años, y en VHA- de 36,6 (DE, 15) años (p = 0,02). Al 44% de los pacientes no se pudo determinar la serología VHA: un 33,6% no respondió a los mensajes telefónicos ni a las cartas enviadas, un 6% estaba ausente temporalmente y un caso no aceptó hacerse la analítica. La respuesta a la realización de la prueba fue mejor en las mujeres (66,7%), en pacientes VIH-(34,7%), en no UDVP (43,3%) y en hepatópatas crónicos (60%). En menores de 40 años, la proporción de seronegativos es similar a la de la población general y se debería considerar la vacunación en todos los pacientes VHC+. En mayores de 40 años y en los pacientes con hepatopatía crónica se debería investigar el estado serológico para vacunar contra la hepatitis A. To investigate the prevalence of immunization against hepatitis A virus (HAV) in persons with hepatitis C virus (HCV) infection, in order to determine who should be vaccinated for the former. Descriptive, cross-sectional study Urban health center serving 12 000 inhabitants. Patients older than 14 years positive for HCV infection. Main measures. Variables: presence of chronic liver disease, serological indications of hepatitis B, A, and immune deficiency virus (HIV) infection, vaccination for hepatitis B. A total of 134 persons (70.9% men and 29.1% women) comprised the sample of patients positive for HCV infection. Mean age was 41.75 years (SD, 16.55 years). Nearly all patients (93.3%) had chronic liver disease, 56.7% were intravenous drug users, 56% were positive for Hbc antibodies and 32.8% were positive for HIV. Serological testing for HAV was done in 75 patients (56%); the result was positive in 86.7%. Mean age in this subgroup was 50.4 years (SD, 17.8 years). In the HAV-negative subgroup, mean age was 36.6 years (SD, 15 years; P=.02). Serological testing for HAV could not be done in 44% of the patients: 33.6% did not respond to attempts to contact them by telephone or in writing, 6% were temporarily away from home, and 1 patient declined to be tested. The response to requests to obtain blood samples was better in women (66.7%), HIV-negative patients (34.7%), persons who were not intravenous drug users (43.3%) and persons with chronic liver disease (60%). In persons younger than 40 years, the proportion of seronegative individuals is similar to that in the general population. Vaccination should be considered for all patients positive for HCV infection. In persons older than 40 years with chronic liver disease, the decision to vaccinate for HAV should be made in the light of serological findings." @default.
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• W2133685976 date "2002-01-01" @default.
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• W2133685976 title "Portadores de hepatitis C: ¿tenemos que vacunarlos a todos frente a la hepatitis A?" @default.
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• W2133685976 doi "https://doi.org/10.1016/s0212-6567(02)78974-9" @default.
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