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- W2133686198 abstract "Cadmium is a ubiquitous environmental metal contaminant with an affinity for biological membranes; it can enter cells by facilitated transport and it binds therein to various biomolecules and affects membrane system function. The relationship between cadmium exposure, dose and response was investigated in the benthic, deposit feeding, marine bivalve Tellina deltoidalis, using 28 day microcosm spiked cadmium exposures. Tissue cadmium reached steady state with the exposure concentration. Half the accumulated cadmium was detoxified and with increased exposure more was converted into metal rich granules. Most biologically active cadmium was in the mitochondrial fraction, with up to 7320-fold cadmium increases in exposed organisms. Cadmium exposed T. deltoidalis generally had reduced glutathione peroxidase enzyme activity. An increase in total glutathione concentrations, due to a build up of oxidised glutathione, was indicated by the reduced to oxidised glutathione ratio. All cadmium exposed T. deltoidalis had reduced total antioxidant capacity that corresponded with increased lipid peroxidation, lysosomal destabilisation and micronuclei frequency. Clear exposure-dose-response relationships have been demonstrated for T. deltoidalis exposed to cadmium-spiked sediments, supporting this organism's suitability for laboratory or in situ evaluation of sediment cadmium toxicity." @default.
- W2133686198 created "2016-06-24" @default.
- W2133686198 creator A5076808471 @default.
- W2133686198 creator A5087100607 @default.
- W2133686198 date "2013-06-01" @default.
- W2133686198 modified "2023-10-14" @default.
- W2133686198 title "Exposure-dose-response of Tellina deltoidalis to metal-contaminated estuarine sediments" @default.
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- W2133686198 doi "https://doi.org/10.1016/j.cbpc.2013.04.005" @default.
- W2133686198 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24100051" @default.
- W2133686198 hasPublicationYear "2013" @default.
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