FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2133695223> ?p ?o ?g. }

• W2133695223 endingPage "985" @default.
• W2133695223 startingPage "981" @default.
• W2133695223 abstract "The nuclear pore complex (NPC) is a protein assembly that contains several distinct subcomplexes. The mammalian nucleoporin (Nup)-107 is part of a hetero-oligomeric complex, that also contains Nup160, Nup133, Nup96, and the mammalian homolog of yeast Sec13p. We used transfection of HeLa cells with small interfering RNAs to specifically deplete mRNA for Nup107. In a domino effect, Nup107 depletion caused codepletion of a subset of other Nups on their protein but not on their mRNA level. Among the affected Nups was a member of the Nup107 subcomplex, Nup133, whereas two other tested members of this complex, Nup96 and Sec13, were unaffected and assembled into Nup107Nup133-deficient NPCs. We also tested several phenylalanine-glycine repeat-containing Nups that serve as docking sites for karyopherins. Some of these, such as Nup358, Nup214 on the cytoplasmic, and Nup153 on the nucleoplasmic side of the NPC, failed to assemble into Nup107Nup133-depleted NPCs, whereas p62, a Nup at the center of the NPC, was unaffected. Interestingly, the filamentous, NPC-associated protein Tpr also failed to assemble into the NPCs of Nup107-depleted cells. These data indicate that Nup107 functions as a keystone Nup that is required for the assembly of a subset of Nups into the NPC. Despite the depletion of Nup107 and the accompanying effects on other Nups, there was no significant effect on the growth rate of these cells and only a partial inhibition of mRNA export. These data indicate redundancy of Nups in the function of the mammalian NPC." @default.
• W2133695223 created "2016-06-24" @default.
• W2133695223 creator A5015374101 @default.
• W2133695223 creator A5019058959 @default.
• W2133695223 creator A5027674094 @default.
• W2133695223 creator A5053846385 @default.
• W2133695223 creator A5081060821 @default.
• W2133695223 date "2003-01-27" @default.
• W2133695223 modified "2023-09-26" @default.
• W2133695223 title "Depletion of a single nucleoporin, Nup107, prevents the assembly of a subset of nucleoporins into the nuclear pore complex" @default.
• W2133695223 cites W1516092312 @default.
• W2133695223 cites W1596438740 @default.
• W2133695223 cites W1611419331 @default.
• W2133695223 cites W190712062 @default.
• W2133695223 cites W1927520851 @default.
• W2133695223 cites W1943832010 @default.
• W2133695223 cites W1967890631 @default.
• W2133695223 cites W1970564598 @default.
• W2133695223 cites W1973052124 @default.
• W2133695223 cites W1974177610 @default.
• W2133695223 cites W1974303913 @default.
• W2133695223 cites W1985732160 @default.
• W2133695223 cites W1999144095 @default.
• W2133695223 cites W2000570159 @default.
• W2133695223 cites W2003556097 @default.
• W2133695223 cites W2010612745 @default.
• W2133695223 cites W2011052397 @default.
• W2133695223 cites W2015646338 @default.
• W2133695223 cites W2016865656 @default.
• W2133695223 cites W2019944861 @default.
• W2133695223 cites W2026512609 @default.
• W2133695223 cites W2043920061 @default.
• W2133695223 cites W2050908337 @default.
• W2133695223 cites W2051567211 @default.
• W2133695223 cites W2053771306 @default.
• W2133695223 cites W2057123629 @default.
• W2133695223 cites W2067514794 @default.
• W2133695223 cites W2084316792 @default.
• W2133695223 cites W2084711835 @default.
• W2133695223 cites W2085304899 @default.
• W2133695223 cites W2095459952 @default.
• W2133695223 cites W2095744767 @default.
• W2133695223 cites W2098020712 @default.
• W2133695223 cites W2098100188 @default.
• W2133695223 cites W2101447312 @default.
• W2133695223 cites W2103656871 @default.
• W2133695223 cites W2105657024 @default.
• W2133695223 cites W2105987719 @default.
• W2133695223 cites W2112349562 @default.
• W2133695223 cites W2133201628 @default.
• W2133695223 cites W2140235777 @default.
• W2133695223 cites W2144786263 @default.
• W2133695223 cites W2151126975 @default.
• W2133695223 cites W2161335608 @default.
• W2133695223 doi "https://doi.org/10.1073/pnas.252749899" @default.
• W2133695223 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/298712" @default.
• W2133695223 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12552102" @default.
• W2133695223 hasPublicationYear "2003" @default.
• W2133695223 type Work @default.
• W2133695223 sameAs 2133695223 @default.
• W2133695223 citedByCount "141" @default.
• W2133695223 countsByYear W21336952232012 @default.
• W2133695223 countsByYear W21336952232013 @default.
• W2133695223 countsByYear W21336952232014 @default.
• W2133695223 countsByYear W21336952232015 @default.
• W2133695223 countsByYear W21336952232016 @default.
• W2133695223 countsByYear W21336952232017 @default.
• W2133695223 countsByYear W21336952232018 @default.
• W2133695223 countsByYear W21336952232019 @default.
• W2133695223 countsByYear W21336952232020 @default.
• W2133695223 countsByYear W21336952232021 @default.
• W2133695223 countsByYear W21336952232022 @default.
• W2133695223 countsByYear W21336952232023 @default.
• W2133695223 crossrefType "journal-article" @default.
• W2133695223 hasAuthorship W2133695223A5015374101 @default.
• W2133695223 hasAuthorship W2133695223A5019058959 @default.
• W2133695223 hasAuthorship W2133695223A5027674094 @default.
• W2133695223 hasAuthorship W2133695223A5053846385 @default.
• W2133695223 hasAuthorship W2133695223A5081060821 @default.
• W2133695223 hasBestOaLocation W21336952231 @default.
• W2133695223 hasConcept C104317684 @default.
• W2133695223 hasConcept C105580179 @default.
• W2133695223 hasConcept C126725582 @default.
• W2133695223 hasConcept C190062978 @default.
• W2133695223 hasConcept C2780114586 @default.
• W2133695223 hasConcept C54009773 @default.
• W2133695223 hasConcept C54355233 @default.
• W2133695223 hasConcept C59157529 @default.
• W2133695223 hasConcept C68556195 @default.
• W2133695223 hasConcept C86803240 @default.
• W2133695223 hasConcept C95444343 @default.
• W2133695223 hasConceptScore W2133695223C104317684 @default.
• W2133695223 hasConceptScore W2133695223C105580179 @default.
• W2133695223 hasConceptScore W2133695223C126725582 @default.
• W2133695223 hasConceptScore W2133695223C190062978 @default.
• W2133695223 hasConceptScore W2133695223C2780114586 @default.
• W2133695223 hasConceptScore W2133695223C54009773 @default.
• W2133695223 hasConceptScore W2133695223C54355233 @default.

• next