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• W2133760293 abstract "D-dimers, specific breakdown fragments of cross-linked fibrin, are generally used as circulating markers of activated coagulation. Statins influence haemostatic factors, but their effect on plasma D-dimer levels is controversial. Therefore, the aim of this meta-analysis was to evaluate the association between statin therapy and plasma D-dimer levels. We searched PubMed, Web of Science, Cochrane Library, Scopus and EMBASE (up to September 25, 2014) to identify randomised controlled trials (RCTs) investigating the impact of statin therapy on plasma D-dimer levels. Two independent reviewers extracted data on study characteristics, methods and outcomes. Meta-analysis of data from nine RCTs with 1,165 participants showed a significant effect of statin therapy in reducing plasma D-dimer levels (standardised mean difference [SMD]: -0.988 µg/ml, 95 % confidence interval [CI]: -1.590 - -0.385, p=0.001). The effect size was robust in sensitivity analysis and omission of no single study significantly changed the overall estimated effect size. In the subgroup analysis, the effect of statins on plasma D-dimer levels was significant only in the subsets of studies with treatment duration ≥ 12 weeks (SMD: -0.761 µg/ml, 95 %CI: -1.163- -0.360; p< 0.001), and for lipophilic statins (atorvastatin and simvastatin) (SMD: -1.364 µg/ml, 95 % CI: -2.202- -0.526; p=0.001). Hydrophilic statins (pravastatin and rosuvastatin) did not significantly reduce plasma D-dimer levels (SMD: -0.237 µg/ml, 95 %CI: -1.140-0.665, p=0.606). This meta-analysis of RCTs suggests a decrease of plasma D-dimer levels after three months of statin therapy, and especially after treatment with lipophilic statins. Well-designed trials are required to validate these results." @default.
• W2133760293 created "2016-06-24" @default.
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• W2133760293 date "2015-01-01" @default.
• W2133760293 modified "2023-10-14" @default.
• W2133760293 title "Association between statin use and plasma D-dimer levels" @default.
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• W2133760293 cites W1586259738 @default.
• W2133760293 cites W1592523562 @default.
• W2133760293 cites W1933011991 @default.
• W2133760293 cites W1972462776 @default.
• W2133760293 cites W1980648524 @default.
• W2133760293 cites W1983483784 @default.
• W2133760293 cites W1986215651 @default.
• W2133760293 cites W1986841915 @default.
• W2133760293 cites W1988366654 @default.
• W2133760293 cites W1996798850 @default.
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• W2133760293 cites W2005947177 @default.
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• W2133760293 cites W2059025617 @default.
• W2133760293 cites W2068886931 @default.
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• W2133760293 cites W2074035327 @default.
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• W2133760293 cites W2313628137 @default.
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• W2133760293 cites W2991792334 @default.
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• W2133760293 doi "https://doi.org/10.1160/th14-11-0937" @default.
• W2133760293 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26017749" @default.
• W2133760293 hasPublicationYear "2015" @default.
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