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• W2133783105 abstract "S ince the first successful renal transplant was performed in 1954, significant progress has been made in overcoming acute host responses to allogeneic tissue and improving supportive care. Because of these advances, transplantation is now widely regarded as the treatment of choice for endstage renal disease. Although l-year allograft survival rates >85%lr are now achieved in many centers, the rates of allograft failure in subsequent years have remained essentially static with a IO-year survival for cadaveric grafts essentially unchanged for decades at <50%.‘~~*~ Consequently, approximately 20% of all patients awaiting kidney transplantation in the United States are previous graft recipients.5 These recurring demands exacerbate the already inadequate supply of donor organs besetting transplant services. Thus, as we near the next millennium, late allograft failure may be regarded as the greatest obstacle to renal transplantation attaining its full potential in the management of end-stage renal disease. When death with a functioning graft is excluded as a cause of late renal allograft loss, a significant though imprecisely defined proportion of kidney transplants fail after a period of gradual loss of function.6,7 Graft losses conforming to this pattern are most likely to be attributed to chronic rejection.E Formerly, this was regarded as an exclusively antigenspecific process mediated by low-grade antibody or cell-mediated immune injury. Recently, a broader perspective has been adopted that includes antigenindependent factors in the pathogenesis of late graft loss. In particular, mechanisms responsible for the progression of chronic renal disease in the setting of reduced renal mass have received considerable attention.417*s-13 This article reviews current literature on the role of one critical antigen-independent determi-" @default.
• W2133783105 created "2016-06-24" @default.
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• W2133783105 creator A5016263167 @default.
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• W2133783105 date "1998-04-01" @default.
• W2133783105 modified "2023-09-23" @default.
• W2133783105 title "Renal mass: An important determinant of late allograft outcome" @default.
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• W2133783105 doi "https://doi.org/10.1016/s0955-470x(98)80032-3" @default.
• W2133783105 hasPublicationYear "1998" @default.
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