Matches in SemOpenAlex for { <https://semopenalex.org/work/W2133802252> ?p ?o ?g. }
- W2133802252 endingPage "283" @default.
- W2133802252 startingPage "275" @default.
- W2133802252 abstract "Insulin resistance is a clinical condition shared by many diseases besides type 2 diabetes (T2DM) such as obesity, polycystic ovary syndrome (PCOS) and non-alcoholic fatty liver disease (NAFLD). Experimental evidence, produced over the years, suggests that metformin has many benefits in the treatment of these diseases. Metformin is a first-line drug in the treatment of overweight and obese type 2 diabetic patients, offering a selective pathophysiological approach by its effect on insulin resistance. Moreover, a number of studies have established the favorable effect of metformin on body weight, not only when evaluating BMI, but also if body mass composition is considered, through the reduction of fat mass. In addition, it reduces insulin resistance, hyperinsulinemia, lipid parameters, arterial hypertension and endothelial dysfunction. In particular, a new formulation of metformin extended-release (ER) is now available with different formulation in different countries. Metformin ER delivers the active drug through hydrated polymers which expand safe uptake of fluid, prolonging gastric transit and delaying drug absorption in the upper gastrointestinal tract. In addition, Metformin ER causes a small, but statistically significant decrease in BMI, when added to a lifestyle intervention program in obese adolescents. Because of the suggested benefits for the treatment of insulin resistance in many clinical conditions, besides type 2 diabetes, the prospective exists that more indications for metformin treatment are becoming a reality." @default.
- W2133802252 created "2016-06-24" @default.
- W2133802252 creator A5014780759 @default.
- W2133802252 creator A5040218313 @default.
- W2133802252 creator A5068223964 @default.
- W2133802252 creator A5080271286 @default.
- W2133802252 date "2014-07-29" @default.
- W2133802252 modified "2023-10-09" @default.
- W2133802252 title "The therapy of insulin resistance in other diseases besides type 2 diabetes" @default.
- W2133802252 cites W1868475579 @default.
- W2133802252 cites W1963683487 @default.
- W2133802252 cites W1964375545 @default.
- W2133802252 cites W1965391363 @default.
- W2133802252 cites W1971400919 @default.
- W2133802252 cites W1972008706 @default.
- W2133802252 cites W1972800410 @default.
- W2133802252 cites W1973401573 @default.
- W2133802252 cites W1974272787 @default.
- W2133802252 cites W1976448511 @default.
- W2133802252 cites W1978128204 @default.
- W2133802252 cites W1978641671 @default.
- W2133802252 cites W1987116578 @default.
- W2133802252 cites W1987669839 @default.
- W2133802252 cites W1987727907 @default.
- W2133802252 cites W1990777401 @default.
- W2133802252 cites W1990878287 @default.
- W2133802252 cites W1993410890 @default.
- W2133802252 cites W1994484905 @default.
- W2133802252 cites W1994646644 @default.
- W2133802252 cites W1996641308 @default.
- W2133802252 cites W2003517642 @default.
- W2133802252 cites W2010949486 @default.
- W2133802252 cites W2012189675 @default.
- W2133802252 cites W2012898950 @default.
- W2133802252 cites W2013962144 @default.
- W2133802252 cites W2013991546 @default.
- W2133802252 cites W2014046105 @default.
- W2133802252 cites W2014304121 @default.
- W2133802252 cites W2014421763 @default.
- W2133802252 cites W2014770821 @default.
- W2133802252 cites W2015252890 @default.
- W2133802252 cites W2019085069 @default.
- W2133802252 cites W2028160831 @default.
- W2133802252 cites W2032627167 @default.
- W2133802252 cites W2034664451 @default.
- W2133802252 cites W2037066238 @default.
- W2133802252 cites W2037777715 @default.
- W2133802252 cites W2039800528 @default.
- W2133802252 cites W2043939998 @default.
- W2133802252 cites W2045107424 @default.
- W2133802252 cites W2046941497 @default.
- W2133802252 cites W2047248124 @default.
- W2133802252 cites W2048685833 @default.
- W2133802252 cites W2052152340 @default.
- W2133802252 cites W2053127486 @default.
- W2133802252 cites W2056505063 @default.
- W2133802252 cites W2058626978 @default.
- W2133802252 cites W2059196301 @default.
- W2133802252 cites W2060963949 @default.
- W2133802252 cites W2062447674 @default.
- W2133802252 cites W2062812115 @default.
- W2133802252 cites W2064675301 @default.
- W2133802252 cites W2066467287 @default.
- W2133802252 cites W2067740038 @default.
- W2133802252 cites W2069232218 @default.
- W2133802252 cites W2070762302 @default.
- W2133802252 cites W2085243036 @default.
- W2133802252 cites W2089391845 @default.
- W2133802252 cites W2089499778 @default.
- W2133802252 cites W2092233192 @default.
- W2133802252 cites W2095365589 @default.
- W2133802252 cites W2097952652 @default.
- W2133802252 cites W2100093159 @default.
- W2133802252 cites W2103156933 @default.
- W2133802252 cites W2114250987 @default.
- W2133802252 cites W2115441589 @default.
- W2133802252 cites W2119890307 @default.
- W2133802252 cites W2127874012 @default.
- W2133802252 cites W2132624542 @default.
- W2133802252 cites W2133184757 @default.
- W2133802252 cites W2138910558 @default.
- W2133802252 cites W2142781702 @default.
- W2133802252 cites W2144654194 @default.
- W2133802252 cites W2144817422 @default.
- W2133802252 cites W2145498419 @default.
- W2133802252 cites W2146901298 @default.
- W2133802252 cites W2148574834 @default.
- W2133802252 cites W2148910524 @default.
- W2133802252 cites W2151901526 @default.
- W2133802252 cites W2153485075 @default.
- W2133802252 cites W2154231321 @default.
- W2133802252 cites W2154355204 @default.
- W2133802252 cites W2155165300 @default.
- W2133802252 cites W2155744138 @default.
- W2133802252 cites W2156480732 @default.
- W2133802252 cites W2171716002 @default.
- W2133802252 cites W2316193238 @default.
- W2133802252 cites W2326830015 @default.