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• W2133802904 abstract "<i>Background/Aims:</i> A single-nucleotide polymorphism (SNP) in the <i>KIBRA</i> gene, rs17070145, was reported to be significantly associated with episodic memory in cognitively normal cohorts. This observation has expanded genetic studies on <i>KIBRA</i> to Alzheimer’s disease (AD). Importantly, the association between <i>KIBRA</i> and episodic memory in AD has never been addressed. In this study, we investigated whether the <i>KIBRA</i> rs17070145 SNP influences AD episodic memory and the disease in a Japanese cohort. <i>Methods:</i> Blood samples from 346 AD patients and 375 normal cognitive controls were collected and genotyped for rs17070145. Episodic memory was measured in 32 AD patients, diagnosed for the first time, by use of the Rivermead Behavioral Memory Test (RBMT). <i>Results:</i> We found that <i>KIBRA</i> C allele carriers scored significantly lower than <i>KIBRA</i> non-C carriers on both RBMT total profile score (p = 0.042, effect size = 0.84) and RBMT total screening score (p < 0.001, effect size = 1.42). The <i>KIBRA</i> gene did not show association with AD in our Japanese cohort. <i>Conclusion:</i> Our results evidence a strong association between the <i>KIBRA</i> gene and episodic memory impairment in AD, but show no influence on AD in our Japanese cohort. We propose that <i>KIBRA</i> might have an effect similar to cognitive reserve." @default.
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• W2133802904 date "2010-01-01" @default.
• W2133802904 modified "2023-10-15" @default.
• W2133802904 title "<i>KIBRA</i> Genetic Polymorphism Influences Episodic Memory in Alzheimer’s Disease, but Does Not Show Association with Disease in a Japanese Cohort" @default.
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• W2133802904 doi "https://doi.org/10.1159/000320482" @default.
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• W2133802904 hasPublicationYear "2010" @default.
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