FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2133809169> ?p ?o ?g. }

• W2133809169 endingPage "810" @default.
• W2133809169 startingPage "801" @default.
• W2133809169 abstract "This study was conducted to determine how extraordinarily high numbers of epidermal growth factor receptors (EGF-R) affected the binding and internalization of EGF in the transformed cell line A431. I found that at low EGF concentrations, the kinetics of binding behaved as a nonsaturable, first-order process showing no evidence of multiple-affinity classes of receptors. However, EGF dissociation rates were strongly dependent on the degree of receptor occupancy in both intact cells and isolated membranes. This occupancy-dependent dissociation appears to be due to diffusion-limited binding. EGF-induced receptor internalization was rapid and first order when the absolute number of occupied receptors was below 4 x 10(3) min-1. However, at higher occupancies the specific internalization rate progressively declined to a final limiting value of 20% normal. The saturation of EGF-R endocytosis was specific since internalization of transferrin receptors was not affected by high concentrations of either transferrin or EGF. Saturation of EGF-R endocytosis probably involves a specific component of the endocytic pathway since fluid phase endocytosis increased coordinately with EGF-R occupancy. I conclude that there are several aspects of EGF-R dynamics on A431 cells are neither similar to the behavior of EGF-R in other cell types nor similar to the reported behavior of other hormone receptors. Although A431 cells have an extraordinary number of EGF-R, they do not seem to have corresponding levels of at least two other crucial cell surface components: one that mediates EGF-induced rapid receptor internalization and one that attenuates EGF-induced membrane responses. These factors, in addition to the presence of diffusion-limited binding at low EGF concentrations, are probably responsible for the appearance of multiple-affinity classes of receptors in this cell type." @default.
• W2133809169 created "2016-06-24" @default.
• W2133809169 creator A5032610249 @default.
• W2133809169 date "1988-08-01" @default.
• W2133809169 modified "2023-10-11" @default.
• W2133809169 title "Anomalous binding of epidermal growth factor to A431 cells is due to the effect of high receptor densities and a saturable endocytic system." @default.
• W2133809169 cites W1497356015 @default.
• W2133809169 cites W1498071142 @default.
• W2133809169 cites W1498549327 @default.
• W2133809169 cites W1542901406 @default.
• W2133809169 cites W1548284562 @default.
• W2133809169 cites W1548966243 @default.
• W2133809169 cites W1567148937 @default.
• W2133809169 cites W1582315378 @default.
• W2133809169 cites W1585720578 @default.
• W2133809169 cites W1589389762 @default.
• W2133809169 cites W1589488717 @default.
• W2133809169 cites W1600133329 @default.
• W2133809169 cites W1606919023 @default.
• W2133809169 cites W1966783283 @default.
• W2133809169 cites W1967626450 @default.
• W2133809169 cites W1973979381 @default.
• W2133809169 cites W1983829372 @default.
• W2133809169 cites W1984927044 @default.
• W2133809169 cites W1986992879 @default.
• W2133809169 cites W1995337883 @default.
• W2133809169 cites W1996683778 @default.
• W2133809169 cites W2002569762 @default.
• W2133809169 cites W2020475637 @default.
• W2133809169 cites W2024184910 @default.
• W2133809169 cites W2025136141 @default.
• W2133809169 cites W2040469480 @default.
• W2133809169 cites W2047897111 @default.
• W2133809169 cites W2049152776 @default.
• W2133809169 cites W2049613194 @default.
• W2133809169 cites W2052246560 @default.
• W2133809169 cites W2062863047 @default.
• W2133809169 cites W2078825008 @default.
• W2133809169 cites W2089144568 @default.
• W2133809169 cites W2093269773 @default.
• W2133809169 cites W2093479997 @default.
• W2133809169 cites W2099335992 @default.
• W2133809169 cites W2131440433 @default.
• W2133809169 cites W2157114921 @default.
• W2133809169 cites W2159321684 @default.
• W2133809169 cites W2161106503 @default.
• W2133809169 cites W2164188238 @default.
• W2133809169 cites W2167983317 @default.
• W2133809169 cites W2176289408 @default.
• W2133809169 cites W2177068955 @default.
• W2133809169 cites W2190289297 @default.
• W2133809169 cites W2197476534 @default.
• W2133809169 cites W2221143007 @default.
• W2133809169 cites W2315421474 @default.
• W2133809169 cites W2414737504 @default.
• W2133809169 cites W976600660 @default.
• W2133809169 doi "https://doi.org/10.1083/jcb.107.2.801" @default.
• W2133809169 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2115211" @default.
• W2133809169 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3262110" @default.
• W2133809169 hasPublicationYear "1988" @default.
• W2133809169 type Work @default.
• W2133809169 sameAs 2133809169 @default.
• W2133809169 citedByCount "229" @default.
• W2133809169 countsByYear W21338091692012 @default.
• W2133809169 countsByYear W21338091692013 @default.
• W2133809169 countsByYear W21338091692014 @default.
• W2133809169 countsByYear W21338091692015 @default.
• W2133809169 countsByYear W21338091692016 @default.
• W2133809169 countsByYear W21338091692017 @default.
• W2133809169 countsByYear W21338091692018 @default.
• W2133809169 countsByYear W21338091692019 @default.
• W2133809169 countsByYear W21338091692020 @default.
• W2133809169 countsByYear W21338091692021 @default.
• W2133809169 countsByYear W21338091692023 @default.
• W2133809169 crossrefType "journal-article" @default.
• W2133809169 hasAuthorship W2133809169A5032610249 @default.
• W2133809169 hasBestOaLocation W21338091691 @default.
• W2133809169 hasConcept C139770010 @default.
• W2133809169 hasConcept C1491633281 @default.
• W2133809169 hasConcept C170493617 @default.
• W2133809169 hasConcept C197462201 @default.
• W2133809169 hasConcept C2776362946 @default.
• W2133809169 hasConcept C28005876 @default.
• W2133809169 hasConcept C29537977 @default.
• W2133809169 hasConcept C32264632 @default.
• W2133809169 hasConcept C47170353 @default.
• W2133809169 hasConcept C55493867 @default.
• W2133809169 hasConcept C67082663 @default.
• W2133809169 hasConcept C79747257 @default.
• W2133809169 hasConcept C86803240 @default.
• W2133809169 hasConcept C95444343 @default.
• W2133809169 hasConceptScore W2133809169C139770010 @default.
• W2133809169 hasConceptScore W2133809169C1491633281 @default.
• W2133809169 hasConceptScore W2133809169C170493617 @default.
• W2133809169 hasConceptScore W2133809169C197462201 @default.
• W2133809169 hasConceptScore W2133809169C2776362946 @default.
• W2133809169 hasConceptScore W2133809169C28005876 @default.
• W2133809169 hasConceptScore W2133809169C29537977 @default.

• next