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- W2133814425 startingPage "S515" @default.
- W2133814425 abstract "This article integrates engineering principles with skeletal biology to describe skeletal strength homeostasis. Skeletal strength revolves around its perceived mechanical usage. Mass, geometric properties, and fatigue damage burden are the principle determinants of structural strength. Bone cells form sensor and effector systems that monitor usage and adjust strength and stiffness by changing mass, geometric properties, and fatigue damage burden. The bone lining cell-osteocyte complex is the sensor; the bone modeling and remodeling systems are the effectors. Deformation and fatigue damage in bone are the signals received by the sensor. Accumulated energy in the sensor's cytoskeleton determines the rate at which the sensor sends messages to the effectors. The activity of both effector systems is proportional to the rate of incoming messages. Modeling raises bone strength and stiffness by improving geometric properties as it adds bone where customary deformation is greatest. Remodeling improves bone strength by replacing fatigue-damaged areas without mass changes. Bone removed during modeling and remodeling comes from sites where the impact on bone strength and stiffness is least. Hormones and agents alter the rigidity of the cytoskeleton and, thus, its capacity to deform and store energy. Osteopenic agents make it more rigid, causing detection of fewer deformations and transmission of fewer loading signals to the effector. Osteotropic agents decrease the rigidity of the cytoskeleton, causing detection of more strain events and transmission of more loading signals to the effector. Agent treatment thus establishes false conditions of disuse or hyperuse." @default.
- W2133814425 created "2016-06-24" @default.
- W2133814425 creator A5002436223 @default.
- W2133814425 date "2009-12-03" @default.
- W2133814425 modified "2023-09-26" @default.
- W2133814425 title "A paradigm for skeletal strength homeostasis" @default.
- W2133814425 cites W1551598476 @default.
- W2133814425 cites W1573798987 @default.
- W2133814425 cites W177807881 @default.
- W2133814425 cites W1891376806 @default.
- W2133814425 cites W1933356227 @default.
- W2133814425 cites W1957370691 @default.
- W2133814425 cites W1964771995 @default.
- W2133814425 cites W1967709376 @default.
- W2133814425 cites W1968738869 @default.
- W2133814425 cites W1972705221 @default.
- W2133814425 cites W1976644662 @default.
- W2133814425 cites W1986032728 @default.
- W2133814425 cites W1986718601 @default.
- W2133814425 cites W1987808432 @default.
- W2133814425 cites W1989689857 @default.
- W2133814425 cites W1990336362 @default.
- W2133814425 cites W1990838989 @default.
- W2133814425 cites W1991847104 @default.
- W2133814425 cites W1992435516 @default.
- W2133814425 cites W1994699261 @default.
- W2133814425 cites W1995535902 @default.
- W2133814425 cites W1996574729 @default.
- W2133814425 cites W1996664794 @default.
- W2133814425 cites W1998573704 @default.
- W2133814425 cites W2001374121 @default.
- W2133814425 cites W2008284657 @default.
- W2133814425 cites W2010013296 @default.
- W2133814425 cites W2010611073 @default.
- W2133814425 cites W2018033196 @default.
- W2133814425 cites W2021250917 @default.
- W2133814425 cites W2023265740 @default.
- W2133814425 cites W2023987420 @default.
- W2133814425 cites W2024382695 @default.
- W2133814425 cites W2026289366 @default.
- W2133814425 cites W2026515194 @default.
- W2133814425 cites W2036055199 @default.
- W2133814425 cites W2036695469 @default.
- W2133814425 cites W2040212265 @default.
- W2133814425 cites W2040850851 @default.
- W2133814425 cites W2041513920 @default.
- W2133814425 cites W2048018515 @default.
- W2133814425 cites W2051947382 @default.
- W2133814425 cites W2052481844 @default.
- W2133814425 cites W2054605913 @default.
- W2133814425 cites W2057779337 @default.
- W2133814425 cites W2058729876 @default.
- W2133814425 cites W2063147677 @default.
- W2133814425 cites W2067623954 @default.
- W2133814425 cites W2070914367 @default.
- W2133814425 cites W2072963204 @default.
- W2133814425 cites W2073637879 @default.
- W2133814425 cites W2077310525 @default.
- W2133814425 cites W2079992192 @default.
- W2133814425 cites W2080535189 @default.
- W2133814425 cites W2080557375 @default.
- W2133814425 cites W2083049128 @default.
- W2133814425 cites W2084579646 @default.
- W2133814425 cites W2084978630 @default.
- W2133814425 cites W2085923662 @default.
- W2133814425 cites W2087733742 @default.
- W2133814425 cites W2088410873 @default.
- W2133814425 cites W2090283784 @default.
- W2133814425 cites W2090303791 @default.
- W2133814425 cites W2090946568 @default.
- W2133814425 cites W2095664458 @default.
- W2133814425 cites W2096550707 @default.
- W2133814425 cites W2117828778 @default.
- W2133814425 cites W2122745505 @default.
- W2133814425 cites W2130082574 @default.
- W2133814425 cites W2130934825 @default.
- W2133814425 cites W2131407581 @default.
- W2133814425 cites W2131992471 @default.
- W2133814425 cites W2133963231 @default.
- W2133814425 cites W2141539220 @default.
- W2133814425 cites W2166307416 @default.
- W2133814425 cites W2417109959 @default.
- W2133814425 cites W25940545 @default.
- W2133814425 cites W4255217118 @default.
- W2133814425 cites W4256493352 @default.
- W2133814425 cites W4292993485 @default.
- W2133814425 doi "https://doi.org/10.1002/jbmr.5650081317" @default.
- W2133814425 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8122521" @default.
- W2133814425 hasPublicationYear "2009" @default.
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