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- W2133816470 abstract "The respiratory tract pathogen Haemophilus influenzae is responsible for a variety of infections in humans including septicemia, bronchitis, pneumonia, and acute otitis media. The pathogenesis of H. influenzae relies on its capacity to resist human host defenses including the complement system, and thus H. influenzae has developed several efficient strategies to circumvent complement attack. In addition to attracting specific host complement regulators directly to the bacterial surface, the capsule, lipooligosaccharides, and several outer membrane proteins contribute to resistance against complement-mediated attacks and hence increased bacterial survival. Insights into the mechanisms of complement evasion by H. influenzae are important for understanding pathogenesis and for developing vaccines and new therapies aimed at patients with, for example, chronic obstructive pulmonary disease. Here we overview current knowledge on the different mechanisms by which H. influenzae evades attack by the host complement system." @default.
- W2133816470 created "2016-06-24" @default.
- W2133816470 creator A5048707669 @default.
- W2133816470 creator A5065108689 @default.
- W2133816470 date "2010-06-01" @default.
- W2133816470 modified "2023-10-07" @default.
- W2133816470 title "Haemophilus influenzae and the complement system" @default.
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- W2133816470 doi "https://doi.org/10.1016/j.tim.2010.03.007" @default.
- W2133816470 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20399102" @default.
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