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- W2133864274 abstract "During periodate degradation of interfering ephedrine, pseudoephedrine, and phenylpropanolamine in the extraction of methamphetamine from urine, it was observed that a small amount of methamphetamine was demethylated to amphetamine. Although all three interfering phenylpropanolamines could be degraded by periodate at pH 5.2 and above, this periodatemediated transformation of methamphetamine to amphetamine was observed only at pH 9.1 and above. Therefore, to avoid this transformation, a pH of 6.2 was used for the oxidative degradation of phenylpropanolamines. The excess periodate was then reduced with thiosulfate or ascorbic acid prior to the extraction of methamphetamine using a basic pH." @default.
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- W2133864274 date "1994-10-01" @default.
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- W2133864274 title "Amphetamine as an Artifact of Methamphetamine during Periodate Degradation of Interfering Ephedrine, Pseudoephedrine, and Phenylpropanolamine: An Improved Procedure for Accurate Quantitation of Amphetamines in Urine" @default.
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- W2133864274 doi "https://doi.org/10.1093/jat/18.6.331" @default.
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