FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2133869212> ?p ?o ?g. }

• W2133869212 endingPage "1935" @default.
• W2133869212 startingPage "1925" @default.
• W2133869212 abstract "Objective— Endothelial microparticles (EMP) are released from activated or apoptotic cells, but their effect on target cells and the exact way of incorporation are largely unknown. We sought to determine the uptake mechanism and the biological effect of EMP on endothelial and endothelial-regenerating cells. Methods and Results— EMP were generated from starved endothelial cells and isolated by ultracentrifugation. Caspase 3 activity assay and terminal deoxynucleotidyl transferase dUTP nick end labeling assay showed that EMP protect target endothelial cells against apoptosis in a dose-dependent manner. Proteomic analysis was performed to identify molecules contained in EMP, which might be involved in EMP uptake. Expression of annexin I in EMP was found and confirmed by Western blot, whereas the corresponding receptor phosphatidylserine receptor was present on endothelial target cells. Silencing either annexin I on EMP or phosphatidylserine receptor on target cells using small interfering RNA showed that the uptake of EMP by human coronary artery endothelial cells is annexin I/phosphatidylserine receptor dependent. Annexin I–downregulated EMP abrogated the EMP-mediated protection against apoptosis of endothelial target cells. p38 activation was found to mediate camptothecin-induced apoptosis. Finally, human coronary artery endothelial cells pretreated with EMP inhibited camptothecin-induced p38 activation. Conclusion— EMP are incorporated by endothelial cells in an annexin I/phosphatidylserine receptor–dependent manner and protect target cells against apoptosis. Inhibition of p38 activity is involved in EMP-mediated protection against apoptosis." @default.
• W2133869212 created "2016-06-24" @default.
• W2133869212 creator A5008177500 @default.
• W2133869212 creator A5008454330 @default.
• W2133869212 creator A5009349672 @default.
• W2133869212 creator A5020690805 @default.
• W2133869212 creator A5026830338 @default.
• W2133869212 creator A5027666301 @default.
• W2133869212 creator A5033276150 @default.
• W2133869212 creator A5044061456 @default.
• W2133869212 creator A5048381562 @default.
• W2133869212 creator A5063825577 @default.
• W2133869212 creator A5067737338 @default.
• W2133869212 creator A5069100205 @default.
• W2133869212 creator A5086415630 @default.
• W2133869212 date "2012-08-01" @default.
• W2133869212 modified "2023-10-18" @default.
• W2133869212 title "Endothelial Microparticle Uptake in Target Cells Is Annexin I/Phosphatidylserine Receptor Dependent and Prevents Apoptosis" @default.
• W2133869212 cites W1555041989 @default.
• W2133869212 cites W1967367827 @default.
• W2133869212 cites W1971219120 @default.
• W2133869212 cites W1985271970 @default.
• W2133869212 cites W1986907064 @default.
• W2133869212 cites W1992361007 @default.
• W2133869212 cites W2004653956 @default.
• W2133869212 cites W2010498435 @default.
• W2133869212 cites W2021861291 @default.
• W2133869212 cites W2026612245 @default.
• W2133869212 cites W2030383998 @default.
• W2133869212 cites W2032946509 @default.
• W2133869212 cites W2036215348 @default.
• W2133869212 cites W2039930764 @default.
• W2133869212 cites W2057116025 @default.
• W2133869212 cites W2074502503 @default.
• W2133869212 cites W2081893638 @default.
• W2133869212 cites W2084908356 @default.
• W2133869212 cites W2088972036 @default.
• W2133869212 cites W2089273197 @default.
• W2133869212 cites W2091239027 @default.
• W2133869212 cites W2091630980 @default.
• W2133869212 cites W2105837096 @default.
• W2133869212 cites W2107149701 @default.
• W2133869212 cites W2124480950 @default.
• W2133869212 cites W2126336279 @default.
• W2133869212 cites W2131287163 @default.
• W2133869212 cites W2146529610 @default.
• W2133869212 cites W2148131489 @default.
• W2133869212 cites W2149776287 @default.
• W2133869212 cites W2154382837 @default.
• W2133869212 cites W2159601997 @default.
• W2133869212 cites W2432844027 @default.
• W2133869212 doi "https://doi.org/10.1161/atvbaha.112.253229" @default.
• W2133869212 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22701020" @default.
• W2133869212 hasPublicationYear "2012" @default.
• W2133869212 type Work @default.
• W2133869212 sameAs 2133869212 @default.
• W2133869212 citedByCount "111" @default.
• W2133869212 countsByYear W21338692122012 @default.
• W2133869212 countsByYear W21338692122013 @default.
• W2133869212 countsByYear W21338692122014 @default.
• W2133869212 countsByYear W21338692122015 @default.
• W2133869212 countsByYear W21338692122016 @default.
• W2133869212 countsByYear W21338692122017 @default.
• W2133869212 countsByYear W21338692122018 @default.
• W2133869212 countsByYear W21338692122019 @default.
• W2133869212 countsByYear W21338692122020 @default.
• W2133869212 countsByYear W21338692122021 @default.
• W2133869212 countsByYear W21338692122022 @default.
• W2133869212 countsByYear W21338692122023 @default.
• W2133869212 crossrefType "journal-article" @default.
• W2133869212 hasAuthorship W2133869212A5008177500 @default.
• W2133869212 hasAuthorship W2133869212A5008454330 @default.
• W2133869212 hasAuthorship W2133869212A5009349672 @default.
• W2133869212 hasAuthorship W2133869212A5020690805 @default.
• W2133869212 hasAuthorship W2133869212A5026830338 @default.
• W2133869212 hasAuthorship W2133869212A5027666301 @default.
• W2133869212 hasAuthorship W2133869212A5033276150 @default.
• W2133869212 hasAuthorship W2133869212A5044061456 @default.
• W2133869212 hasAuthorship W2133869212A5048381562 @default.
• W2133869212 hasAuthorship W2133869212A5063825577 @default.
• W2133869212 hasAuthorship W2133869212A5067737338 @default.
• W2133869212 hasAuthorship W2133869212A5069100205 @default.
• W2133869212 hasAuthorship W2133869212A5086415630 @default.
• W2133869212 hasBestOaLocation W21338692121 @default.
• W2133869212 hasConcept C123012128 @default.
• W2133869212 hasConcept C153911025 @default.
• W2133869212 hasConcept C185592680 @default.
• W2133869212 hasConcept C190283241 @default.
• W2133869212 hasConcept C202751555 @default.
• W2133869212 hasConcept C22615655 @default.
• W2133869212 hasConcept C2778918659 @default.
• W2133869212 hasConcept C2779637612 @default.
• W2133869212 hasConcept C2780670749 @default.
• W2133869212 hasConcept C41625074 @default.
• W2133869212 hasConcept C51551487 @default.
• W2133869212 hasConcept C54009773 @default.
• W2133869212 hasConcept C54355233 @default.
• W2133869212 hasConcept C55493867 @default.

• next